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Neuroimaging in the era of biologically defined Alzheimer's disease and disease-modifying therapy.

Tammie L S Benzinger, Petrice M Cogswell, Arvin Arani et al.The Lancet. Neurology

The efficacy of modified psychodynamic psychotherapy for patients with schizophrenia-spectrum disorders in Germany: a prospective, single-centre, assessor-blinded, parallel-group, randomised controlled trial.

Christiane Montag, Anna-Lena Bröcker, Samuel Bayer et al.The lancet. Psychiatry

Beyond individual-level approaches to dementia prevention: a socioecological reappraisal.

Jennifer Dunne, Mario Siervo, Kaarin J Anstey et al.The Lancet. Public health

Toxicological and Clinical Characteristics of Fatal Cases in the Emerging Drugs Network of Australia-Victoria (EDNAV) Clinical Registry 2020-2025.

James White, Sarah J Hampton, Shaun GreeneEmergency medicine Australasia : EMA

The path to treating multiple-etiology dementia: Combining vascular risk control and disease-modifying neurodegenerative therapies.

Adam de Havenon, Kevin N Sheth, Carolyn A Fredericks et al.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Multiple-etiology dementia (MED), typically characterized by coexisting vascular and neurodegenerative pathology, is the most common cause of late-life cognitive impairment. Autopsy and biomarker studies demonstrate frequent overlap between cerebral small vessel disease, stroke-related injury, amyloid-β deposition, and tau pathology, yet therapeutic development has…

Targeting TLR4/NF-κB/NLRP3 signaling with 6-hydroxyflavanone mitigates amyloid-β-induced Alzheimer's disease in mice.

Debarati Rakshit, Mohit Nema, Awanish MishraBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Implicitly tuned: The neural effects of social feedback on adolescent learning.

Alexis N Bosseler, Erica Peterson, Katherine K Meltzoff et al.Developmental cognitive neuroscience

Psychological stress and tumor progression: Molecular mechanisms and therapeutic implications (Review).

Yifei Zhang, Yajun Kong, Shuanbao ZhaoOncology letters

Early Life Vascular Risk and Midlife Markers of Brain Aging.

Shahin Yaghoobi, Fatemeh Salboukh, Donald Llyod-Jones et al.Stroke

An etiological approach to psychosis: potential benefits for treatment, research and prevention.

Robin M Murray, Dominic Oliver, Aikaterini Dima et al.World psychiatry : official journal of the World Psychiatric Association (WPA)

Pharmacological modulation of cGAS-STING-NLRP3 signaling by nano-immunomodulators in Alzheimer and Parkinson disease.

Mohammed A Abdel-RasolInflammopharmacology

Neuroinflammation is a central driver of neurodegeneration in Alzheimer's disease (AD) and Parkinson's disease (PD), driven by interconnected pathways involving microglial state dysregulation, inflammasome activation, cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling, impaired mitophagy, CD33-TREM2 imbalance, gut-brain axis disruption, and peripheral immune…

Early differences in neural adaptation to written words before reading instruction in dyslexia.

Anna Banaszkiewicz, Katarzyna Chyl-Tanaś, Hanna Górecka et al.Developmental cognitive neuroscience

BRAINet: a brain-region-aware interaction network for EEG-based diagnosis of disorders of consciousness.

Haoxiang Chen, Sha Zhao, Jie Yu et al.Journal of neural engineering

Hypoglossal motor output is altered by C4 epidural electrical stimulation via ascending spinal and peripheral feedback pathways.

Alyssa R Mickle, Jesús D Peñaloza-Aponte, Caitlin Brennan et al.Journal of neurophysiology

Use of neurostimulation in patients with treatment-resistant depression: current options and future directions.

Yoshihiro NodaExpert review of medical devices

Recent developments in donepezil-based hybrid molecules as multi-target therapeutics for Alzheimer's disease: A paradigm shift beyond symptomatic treatment.

Nitin Kumar, Izhar Khan, Jyoti Singh et al.Bioorganic chemistry

Deep learning-driven discovery and optimization of natural LSD1 inhibitors for the treatment of Alzheimer's disease.

Zhonghua Li, Tiancheng Sun, Mengyu Han et al.Bioorganic chemistry

cis-γ-Amino-L-proline peptides as chemical probes of amyloidogenic processing in neurons and APP/PS1 mice.

Dayaneth Jácome, Marina Pérez-Palau, Inés Martínez-Soria et al.Bioorganic chemistry

Design synthesis and evaluation of usnic acid derivatives as multi-target drugs for Alzheimer's disease.

Yin-Sheng Quan, Jin-Ying Liu, Hui Liu et al.Bioorganic chemistry

Nanotechnological and in vivo characterization of a new generation of brain-permeable nanoparticles for brain-targeted cholesterol delivery in Huntington's disease.

Giulia Birolini, Martina Vitali, Ilaria Ottonelli et al.International journal of pharmaceutics