La ricerca in psicologia,
più accessibile.

Mindfulness-based interventions in psychopedagogy for students with Attention Deficit Hyperactivity Disorder (ADHD): a scoping review.

Yépez-Verduga JV, Villacis-Macias CDFrontiers in psychology

IntroductionMindfulness-based interventions have gained increasing relevance as complementary strategies for addressing attentional, behavioral, and emotional difficulties in individuals with Attention Deficit Hyperactivity Disorder (ADHD). This study aimed to systematically map and analyze the scientific evidence on mindfulness-based interventions in populations with ADHD, focusing…

Next-generation microbiome therapeutics: psychobiotics and fecal microbiota transplants for mental health treatment.

Selta DRF, Abraham L, Kavitha R et al.Frontiers in cellular and infection microbiology

The human gastrointestinal tract (GIT) harbors a diverse microbial community, collectively referred to as gut microbiota, which plays an essential role in maintaining host physiology, metabolism, immune function, and neurobehavioral processes. Mounting evidence highlights the importance of the bidirectional Gut-brain (GB) axis, through…

Vanderbilt Integrated Community TMS for Opioid Recovery (VICTORY): Study protocol for a randomized, controlled trial of non-invasive brain stimulation to reduce craving in people with opioid use disorder.

Kathryn Biernacki, Jillian Connolly, Libby Tunison et al.PloS one

BACKGROUND: Individuals receiving buprenorphine treatment for opioid use disorder (OUD) remain at high risk for treatment discontinuation and return to opioid use. Transcranial magnetic stimulation (TMS) has shown efficacy in reducing craving and substance use in other substance use disorders, but its application…

Calmodulin controls spatial and temporal specificity of calcium-induced calcium release.

Joanna Jędrzejewska-Szmek, Kim T BlackwellPLoS computational biology

Calcium dynamics controls learning and memory, and abnormal calcium dynamics have been implicated in neurodegenerative disorders, such as Alzheimer's disease (AD). Calcium dynamics are influenced by calcium-induced calcium release (CICR), which is mediated by ryanodine receptors (RyR) located on endoplasmic reticulum (ER) membrane.…

Clues to immune havoc in the brain.

Jennie Erin SmithScience (New York, N.Y.)

Caregiving Reconsidered: How Confounding Helping with Suffering has Obscured a Major Health-Promoting Behavior.

Naomi I Eisenberger, Flora Blandl, Maria NaclerioBiopsychosocial science and medicine

Selective interoception impairments and treatment effects in borderline personality disorder.

Jella Voelter, Danilo Postin, Christina Müller et al.Translational psychiatry

Patients with borderline personality disorder (BPD) suffer from severe emotional dysregulation and disturbances in body image and self-perception. Interoception, the processing and perception of internal body signals, is closely linked to emotional processing, but it remains unclear whether BPD impairs specific interoceptive facets…

Spatial covariance of mGluR5 density and structural degeneration in behavioral variant frontotemporal degeneration.

Melanie A Matyi, Maggie K Pecsok, Christopher A Olm et al.Imaging neuroscience (Cambridge, Mass.)

Post-mortem human brain tissue and in vivo imaging studies of behavioral variant frontotemporal degeneration (bvFTD) suggest that metabotropic glutamate receptors (mGluR) may be vulnerable to the disease process. However, these studies lack evidence demonstrating how loss of mGluR relates to clinical features of…

Social approach-avoidance conflict: Behavioural, emotional, and neural correlates along a depression-social anxiety spectrum.

Francisco Cervantes Constantino, Alejo Acuña, Catalina Fernandez et al.Imaging neuroscience (Cambridge, Mass.)

Approach-avoidance conflict, in which the same option entails both rewarding and aversive consequences, has been proposed as a key process in internalizing disorders such as depression and social anxiety. Yet, human paradigms that model approach-avoidance conflict and link it to brain function remain…

Unmasking concealed depression through the digital leakage effect: A narrative review and theoretical framework with implications for asian populations.

Chunlin Fu, Dan Su, Junjie Zhang et al.Asian journal of psychiatry

Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer's vulnerability.

Bernard Mulvey, Heena R Divecha, Madhavi Tippani et al.Acta neuropathologica

What Static Connectivity Misses: Dynamic Alpha-Band Brain Network States in First-Episode Psychosis.

Romain Aubonnet, Mahmoud Hassan, Paolo Gargiulo et al.Brain topography

This study investigates resting-state EEG alpha-band connectivity in first-episode psychosis (FEP) using a novel dynamic connectivity pipeline and examines its relationship with cognitive functioning and psychopathological scores. Data from 78 individuals with FEP and 60 healthy controls (CTR) were analyzed. Source estimation was…

Chronic kidney disease and cognitive decline: choroid plexus remodeling, glymphatic dysfunction, and alzheimer biomarker interpretation.

Lucas Maciel de Almeida Corrêa, Rebeca Oliveira da Silva, Luiggi Kevin Virgino Brandão et al.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

BACKGROUND: Cognitive impairment is common in chronic kidney disease (CKD), yet vascular, uremic, dialysis-related, and neurodegenerative mechanisms are often considered separately. We propose an integrated kidney-brain tissue-environment framework to support neurological interpretation of cognitive, imaging, and biomarker findings in CKD. METHODS: We conducted…

Design, synthesis and multitarget evaluation of cyclopropyl-appended thiohydantoin derivatives as dual cholinesterase and COX inhibitors with antioxidant activity: a combined experimental and computational study.

Amina Hussain, Rafaqat Hussain, Hina Sarfraz et al.Journal of computer-aided molecular design

Abortive transcripts in exosomes - A potential biomarker for Alzheimer's disease.

Haizhu Wu, Na Zhang, Weiwei Yan et al.PloS one

Diagnosis of Alzheimer's disease (AD) relies on invasive cerebrospinal fluid analysis or costly neuroimaging, underscoring the need for minimally invasive blood-based biomarkers for early detection. Exosomes, promising biomarker carriers, are unexplored for ultra-short RNA species like abortive transcripts (ATs). We investigated whether 8-nucleotide…

Individual circulating microRNAs and continuous cognitive performance in a mixed inpatient-outpatient geriatric cohort: A cross-sectional pilot study.

Krzysztof Wilczyński, Wojciech Garczorz, Agnieszka Kosowska et al.PloS one

BACKGROUND: Circulating microRNAs have been proposed as minimally invasive markers of cognitive impairment and neurodegenerative disease, but evidence for individual miRNAs in heterogeneous older populations remains limited. OBJECTIVE: We examined cross-sectional associations between eight circulating serum miRNAs and continuous cognitive performance in a…

Elucidating the role of DEAF1 in neurodevelopment and shared molecular pathways in high-risk autism genes using cortical organoids.

Jonghun Kim, Mu Seog Choe, Woo Sub Yang et al.Science advances

Computational mechanisms of perception in autism revealed using games inspired by rodent operant tasks.

Sucheta Chakravarty, Quan Do, Yutong Li et al.Science advances

Altered perception is a hallmark of autism spectrum disorder (ASD), yet its underlying mechanisms remain unclear, in part because individuals with greater impairments are often excluded from psychophysics research. Here, we introduce GEODE (gathering evidence to optimize decisions), an online video game designed…

Acute psychosis unmasking severe non-ischaemic cardiomyopathy with biventricular thrombosis and cardioembolic cerebral infarcts.

Bushra Elhusein, Rashma Khan-Kisitu, Alex HofkirchnerBMJ case reports

Do all roads lead to Rome? A qualitative process evaluation of two types of group-based Behavioural Activation following acquired brain injury from the MAPLES feasibility trial.

Andrea Kusec, Ron Bennett, Estela Carmona et al.Neuropsychological rehabilitation