Design, synthesis and multitarget evaluation of cyclopropyl-appended thiohydantoin derivatives as dual cholinesterase and COX inhibitors with antioxidant activity: a combined experimental and computational study.
Journal of computer-aided molecular design · 2026
Abstract e pubblicazione originale
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Leggi nella fonte originale ↗Parole chiave
Cholinesterase InhibitorsAntioxidantsMolecular Docking SimulationDrug DesignHumansStructure-Activity RelationshipCyclooxygenase 2 InhibitorsCyclooxygenase 2Alzheimer DiseaseAcetylcholinesteraseCyclooxygenase InhibitorsAlzheimer diseaseCOX-2CholinesteraseCyclopropylMolecular dockingStructure activity relationshipsThiohydantoin derivatives
Come citare questo studio
Amina Hussain, Rafaqat Hussain, Hina Sarfraz, Uzma Azam, Muhammad Hasnat, Shoaib Khan, Sibghat Mansoor Rana, Yazeed M Asiri, Zainab. (2026). Design, synthesis and multitarget evaluation of cyclopropyl-appended thiohydantoin derivatives as dual cholinesterase and COX inhibitors with antioxidant activity: a combined experimental and computational study.. Journal of computer-aided molecular design. DOI: 10.1007/s10822-026-00939-7
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