13 Novembre 2026

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2026Altra ricercaTesto disponibile

Virtual Flood Experience Enhances Preparedness Through Emotional and Neural Engagement.

Fujimi T, Kochiyama T, Sato W et al.Risk analysis : an official publication of the Society for Risk Analysis

As climate change intensifies flood risks, strengthening individual preparedness is essential for sustainable societies. This study tested whether first-person three-dimensional computer graphics (3DCG) flood videos can complement official flood maps in motivating preparedness. We used these materials as operationalizations of experiential and descriptive…

2026Altra ricercaTesto disponibile

Stable episodic memory and higher education do not influence the rate of Alzheimer's disease pathology as measured by plasma p-tau217.

Bárbara Avelar-Pereira, Nicola Spotorno, Anna Orduña Dolado et al.Alzheimer's & dementia : the journal of the Alzheimer's Association

INTRODUCTION: Blood-based biomarkers, particularly phosphorylated tau 217 (p-tau217), can detect early Alzheimer's disease (AD) neuropathological changes. Recent work has shown that p-tau217 is lower in individuals with stable cognition and higher education. These factors may protect against AD pathology. METHODS: We evaluated whether…

2026Altra ricercaTesto disponibile

Measurement precision matters: Accounting for uncertainty alters estimated memory trajectories across the cognitive spectrum.

Emily H Trittschuh, Phoebe Scollard, Paul K Crane et al.Alzheimer's & dementia : the journal of the Alzheimer's Association

INTRODUCTION: Harmonized cognitive composites are widely used to study longitudinal cognitive decline. Although harmonization places scores on a common latent scale, measurement precision varies across visits, age, and diagnosis, but is typically ignored in longitudinal models. METHODS: We analyzed harmonized memory scores and…

2026Altra ricercaTesto disponibile

The Vicious Cycle of Sleep Disruption and Inflammaging: Mechanisms, Consequences, and Therapeutic Opportunities.

Fu-Ying Zhao, Jia-Mei Wang, Shi-Yang Lu et al.Aging cell

Aging is characterized by two interdependent hallmarks: a chronic low-grade inflammatory state known as inflammaging, and a progressive deterioration of sleep and circadian rhythms. Emerging evidence indicates that these are not merely parallel processes but are mechanistically intertwined in a self-perpetuating cycle. This…

2026MetanalisiTesto disponibile

The shared genetic architecture of the TDP-43 spectrum: Bridging clinical FTLD and neuropathological endophenotypes.

Maulikkumar Patel, Pawan Kumar, Daniel Western et al.Alzheimer's & dementia : the journal of the Alzheimer's Association

INTRODUCTION: TAR DNA-binding protein 43 (TDP-43) proteinopathies encompass a spectrum of conditions including frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), limbic-predominant age-related TDP-43 encephalopathy (LATE-NC), and hippocampal sclerosis (HS). FTLD-TDP is further classified into several pathological subtypes (A, B, C, D, and E),…

2026Altra ricercaTesto disponibile

Geriatric Emergency Management Programs and Days at Home Among People Living With Dementia in Ontario.

Margret Lo, James Lee, Emily Bagley et al.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

BACKGROUND: People living with dementia frequently present to emergency departments (EDs) and are at increased risk of hospitalization, institutionalization, and other adverse outcomes. Geriatric Emergency Management (GEM) programs are designed to improve emergency care for older adults, but their effectiveness among people living…

2026Altra ricercaTesto disponibile

Intrathecal Transplantation of Human Umbilical Cord-Derived MSCs Outperforms Intravenous Administration in Attenuating Pathology and Cognitive Deficits in Alzheimer's Disease Mice.

Li Ding, Wei Yu, Yuqian Chen et al.CNS neuroscience & therapeutics

BACKGROUND: Mesenchymal stem cell (MSC)-based therapies have emerged as a promising approach for Alzheimer's disease (AD), owing to their neuroprotective, anti-inflammatory, and immunomodulatory properties. However, the optimal delivery route for maximizing therapeutic efficacy within the central nervous system remains unclear. This study aimed…

2026Altra ricercaTesto disponibile

Work characteristics and mental health among physicians in Bangladesh: highlighting gendered perspectives.

Alpona AB, Rupa SA, Kurniawan RD et al.BJPsych international

BACKGROUND: Work characteristics play a crucial role in the mental well-being of physicians. However, limited research in Bangladesh has explored the association between these characteristics and specific mental health outcomes such as depression, anxiety and stress among physicians, particularly in relation to gender…