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Lactoferrin Modulates Intestinal Morphology and Microbiota Homeostasis in Chronic Social Defeat Stress Mice.

Orzeł-Gajowik K, Popek M, Sulej Z et al.Molecules (Basel, Switzerland)

Chronic social stress is increasingly linked to gut-brain axis dysfunction, yet gut-targeted interventions remain underexplored. This study investigated whether oral lactoferrin (L) administration modulates the intestinal and behavioral consequences of chronic social defeat stress (CSDS) in male C57BL/6J mice. Animals were randomly assigned…

Low-frequency passive mechanical stimulation produces antidepressant-like effects in rats involving gut-brain axis modulation.

Gao R, Pu W, Lv Y et al.Frontiers in immunology

IntroductionDepression is associated with dysregulation of neuroendocrine, immune, and gut -brain axis pathways. Exercise is an effective non-pharmacological intervention; however, poor motivation and fatigue limit adherence in patients with depression.MethodsWe investigated a novel passive exercise modality, low-frequency passive vertical oscillation assisted by elastic…

Architect or Destroyer: The Diversity of Glucocorticoid Receptor Signaling Pathways in the Brain.

Shkarina L, Khaybullina R, Primak A et al.International journal of molecular sciences

Glucocorticoids (GCs), acting through the glucocorticoid (GR) and mineralocorticoid (MR) receptors, are essential for brain development, stress adaptation, and metabolic homeostasis, yet their signaling exhibits context-dependent diversity yielding either beneficial or detrimental outcomes. This review synthesizes current knowledge on the multifaceted mechanisms through…

Mayonnaise intake and depression: dose-response in humans and neurobehavioral and molecular mechanisms in zebrafish.

Yao Z, Dong X, Liu X et al.Biochemistry and biophysics reports

Association of Copy Number Variations in PTEN with Autism Spectrum Disorder.

Xu Zheng, Ran Tan, Yuze Wang et al.Genes

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong genetic basis. While copy number variations (CNVs) significantly contribute to ASD risk, the specific role of individual genes within these variants remains unclear. This study investigates the contribution of CNVs…

Shared Genetic and Regulatory Architecture of Congenital Heart Disease and Autism Spectrum Disorder Revealed by Cross-Tissue Multi-Omic Integration.

Min Zhu, Jingkun Fred Zhang, Stella X Hu et al.Genes

Background: Congenital heart disease (CHD) and autism spectrum disorder (ASD) co-occur more frequently than expected, suggesting shared developmental susceptibility. We aimed to identify cross-tissue molecular candidates linking cardiac and neurodevelopmental abnormalities. Methods: CHD- and ASD-associated genes were curated from MalaCards and SFARI Gene,…

From Insulin Resistance to Mitochondrial Failure: A Staged Model of Impaired Metabolic Flexibility in Schizophrenia.

Myles Cubitt, Bart Ellenbroek, Anne M HaaseBiomolecules

Schizophrenia is a highly heritable neuropsychiatric disorder whose pathophysiology remains poorly understood. While neurotransmitter, neurodevelopmental, synaptic, and dysconnectivity hypotheses explain important aspects of the disorder, growing evidence suggests that metabolic dysfunction also plays a central role. This narrative review synthesises evidence from genetics,…

Identification of RNA-Binding Proteins Regulating the Alternative Splicing of TREM2 Exon 4.

Hina Yamada, Motoaki Yanaizu, Naoki Iwai et al.Genes

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline. Most AD cases are sporadic, with both environmental and genetic factors contributing to disease onset and progression. TREM2, an AD susceptibility gene, encodes a receptor protein expressed on the plasma…

Gut-Directed Hypnotherapy: An Option to Enhance the Biopsychosocial Treatment of Disorders of Gut-Brain Interaction.

Whorwell PJBrain sciences

The most common gastrointestinal disorders encountered in secondary care are the functional gastrointestinal disorders, now known as disorders of gut brain interaction (DGBI) of which irritable bowel syndrome (IBS) is the most prevalent example. The pathophysiology of these conditions is beginning to be…

Association of the Schizophrenia Risk Locus rs10866912 with Cerebral Volumes, Diet, and Psychosis in the UK Biobank.

Jankowski L, Periyasamy S, Youssef P et al.Genes

BACKGROUND: Leading schizophrenia GWAS signals require evaluation of their pathological significance across diverse ancestries. rs10866912 reached genome-wide significance in our Indian ancestry GWAS of schizophrenia; its risk allele reduces expression of NAPRT, the rate-limiting enzyme in the brain's principal NAD+-synthesis pathway, giving a…

Associations of Blood Lipid Traits with Cognitive-Related Outcomes and Their Sensitivity to APOE-Region Instrumental Variables: A Mendelian Randomization and Colocalization Study.

Xiaoya Tian, Xiaolin XueGenes

Background: Neurodegenerative, cognitive, and cerebrovascular outcomes are central to brain health. Previous studies have linked blood lipid traits to these outcomes, but associations differ across lipid components and outcome types. However, the contribution of APOE remains unclear. We compared these patterns, quantified their…

A tool to evaluate the impact of lived experience involvement in research: the Brain and Genomics Hub Impact Log protocol.

Gergel T, Wright T, Geshica L et al.Wellcome open research

BackgroundDespite widespread recognition of the value of lived experience involvement (LEI) in healthcare research and increased LE involvement activity, we lack established implementation methods and instruments for reporting and evaluating impact. We present a protocol for an innovative LE-led Impact Log tool and…

Rational Drug Use Support System: design, artificial intelligence integration, and pilot feasibility trial.

Kahraman M, Bozkurt ME, Kotan S et al.Revista da Associacao Medica Brasileira (1992)

Nano-totalitarianism: Brain-computer interfaces, fusion databases, and the weaponisation of consciousness.

Hawkins JKTorture : quarterly journal on rehabilitation of torture victims and prevention of torture

Case 351: Thalamic Dementia Secondary to Dural Arteriovenous Fistula.

Surrin Shazam Deen, Bobak Khalili, Kapil Semalti et al.Radiology

Examining the Impact of Neurodevelopmental Nicotine Exposure on Cortical Excitation/Inhibition Homeostasis Markers in a Cerebral Organoid Model of Schizophrenia.

Kuralay Zhaksylyk, Mohammed H Sarikahya, Enzo Pérez-Valenzuela et al.Journal of neurochemistry

Somatic Blood Mosaicism and Psychiatric Disease: Current Evidence and Causal Limits.

Belbe AA, Pîrlog LM, Pilatec AN et al.Genes

Somatic blood mosaicism is an established feature of ageing and a heterogeneous marker of haematologic cancer and inflammatory and vascular risk, but its psychiatric evidence base remains small. This structured critical narrative review evaluates mutation-defined clonal haematopoiesis, clonal haematopoiesis of indeterminate potential (CHIP),…

Nonlinear Feature Modeling Using Kolmogorov-Arnold Networks in Electroencephalography for Depression Classification: Deep Learning Study.

Yang B, Fan Y, Wei X et al.JMIR AI

BackgroundDepression is a common mental disorder that seriously affects mental health and quality of life. Traditional depression diagnosis mainly relies on clinical interviews and subjective assessments, which may lead to variability in diagnostic outcomes. Electroencephalogram (EEG)-based computer-aided diagnosis has emerged as a promising,…

Priming the Brain Before Chemotherapy: Chronic Stress and HPA-Axis Dysregulation in Cancer-Related Cognitive Impairment.

Andrews L, El Khaldi Y, George T et al.Brain sciences

Cancer-related cognitive impairment (CRCI) is often attributed to chemotherapy, yet cognitive deficits are detectable in some patients before systemic treatment begins. This review examines a proposed two-hit framework in which cancer-related psychological and physiological stress contributes to pretreatment neural vulnerability, followed by superimposed…

Exploratory Metabolomic and Metagenomic Profiling of Fecal Samples in Isolated REM Sleep Behavior Disorder.

Fabio Ascari, Luca Baldelli, Daniel Scicchitano et al.Biomolecules

Isolated REM sleep behavior disorder (iRBD) is among the most reliable prodromal markers of α-synucleinopathies. Under the body-first (gut-first) model of α-synuclein pathology, in which pathology may originate in the enteric nervous system and ascend to the brain, the gut is a biologically…