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An oxidized ribonucleotide 8-oxoGTP drives neuroinflammation and accelerates cognitive decline.

Jin Li, Zhen-He Wang, Jia-Xin Pan et al.Science advances

Intrinsic Activity Reductions and Cerebello-Cortical Diaschisis-Like Mechanism in Friedreich Ataxia: An fALFF Resting-State fMRI Study.

Naeije Gilles, Trotta Nicola, Rovai AntoninBrain and behavior

BACKGROUND: Friedreich ataxia (FA) is characterized by progressive degeneration of the cerebellum and its output pathways, particularly the dentato-thalamo-cortical system, leading to motor impairment and the cerebellar cognitive affective syndrome (CCAS). Resting-state fMRI studies in FA have focused on alterations of long-range functional…

The Effects of Mind-Body Exercise on Cognitive Function and Peripheral Blood BDNF in Elderly People With Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.

Ni Dong, Bing Zeng, Qilong Wang et al.Geriatrics & gerontology international

Disaggregating between- and within- person effects of ovarian hormones on the association between worry and error-related brain activity in a female sample

Louis C, Gloe L, Guevarra D et al.Scientific reports

Brain functional changes of suicidal ideation and behaviours: a meta-analysis of task-based fMRI studies.

Xu VE, Fang KK, Shao RTranslational psychiatry

Anterior part of fronto-temporal language network as the neural basis of morphologically structured word form processing: evidence from Korean morphologically complex word.

Kim J, Nam KBMC neuroscience

Navigating adulthood with maple syrup urine disease: patient and caregiver perspectives on healthcare transition and independent living.

Gold JI, Grabill M, Dolins K et al.Orphanet journal of rare diseases

Climate Change and Pediatric Gastrointestinal Health: A Narrative Review.

Kuhn A, Dugar S, Shah M et al.Gastro hep advances

In 2025, the United Nations acknowledged that the world has failed to reduce carbon emissions sufficiently to avoid 1.5C warming-the level set by the Paris Accords to avoid devastating consequences. Communities already feel the implications of climate change, and it is creating new…

Chronic stress activates a hypothalamic vagal circuit to promote hepatocellular carcinoma progression in male mice.

Zhang K, Zhang J, Chi D et al.Nature communications

Operative challenges and functional outcomes of salvage microsurgery in Gamma Knife-failed vestibular schwannoma: A 12-year institutional experience.

Birua GJS, Sadashiva N, Thimmarayappa A et al.Clinical neurology and neurosurgery

The Effects of a Multi-Strain Probiotic Formulation Containing Saffron Extract and Fructooligosaccharides on Anxiety, Depressive Symptoms, Inflammatory Markers, and BDNF: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.

Demetriou M, Theleritis C, Alevyzakis E et al.Microorganisms

Depression and anxiety are highly prevalent mental health conditions, with growing evidence implicating the gut-brain-immune axis in their pathophysiology. Probiotic supplementation has emerged as a potential psychobiotic intervention, although clinical findings remain inconsistent. This double-blind, randomized, placebo-controlled pilot study assessed the feasibility of…

Temporal brain dynamics and fluid reasoning after extreme prematurity.

Padilla N, Escrichs A, Del Agua E et al.Cerebral cortex (New York, N.Y. : 1991)

Extremely preterm (EPT) birth (

Expression of the long noncoding RNA Neat1 in saliva, blood, and ventromedial hypothalamus of pigs exposed to psychosocial stressors.

Webster D, Ding L, Zhang S et al.Physiological reports

The long noncoding RNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) is a master regulator of transcriptional and posttranscriptional changes in stress responses. Here we assessed Neat1 lncRNA expression using quantitative PCR in peripheral biological fluids (saliva and blood) and a brain region that…

Beyond Dissemination: From Critical Science Literacy to Citizen Neuroscience.

Raschle NM, Federici E, Hauser T et al.The European journal of neuroscience

Unveiling the Underexplored Neurotoxicity of 2,6-Dichloro-1,4-benzoquinone: Insights from Network Toxicology and In Vivo Models.

Wei S, Cao M, Bao J et al.Environmental science & technology

Integrative Transcriptomics and Machine Learning Identify Temporal Stress Signatures and Astrocytic Neurocan Associated With Hypothalamic Injury.

Zhu W, Li C, He M et al.CNS neuroscience & therapeutics

BackgroundStress-related neurological dysfunction evolves dynamically, but molecular markers distinguishing stress stages remain limited. We aimed to characterize temporal hypothalamic transcriptomic changes and identify molecular signatures for stress-stage discrimination.MethodsWhole-transcriptome sequencing was performed in mouse hypothalami after stress. Differential expression, temporal clustering, co-expression network analysis,…

The NLRP3 inflammasome as a bridge between myocardial infarction and depression: mechanisms, bidirectional link, and therapeutic potential.

Zhou P, Ma Y, Hou C et al.Frontiers in cardiovascular medicine

Myocardial infarction (MI) and depression frequently co-occur and form a bidirectional relationship that worsens patient outcomes, with inflammation serving as a core mechanism linking these two disorders. The NLRP3 inflammasome, a key component of the innate immune system, plays a pivotal role in…

A robust adversarial learning framework for EEG emotion recognition.

Yang H, Chen L, Gao J et al.Frontiers in neurology

Asparagine Synthetase Deficiency: A Novel ASNS Variant and a Systematic Review of Clinical Phenotypes and Cerebrospinal Fluid Asparagine Levels.

Patryk Lipiński, Sandra Górska, Julia Brąszkiewicz et al.Biomolecules

BACKGROUND: Asparagine synthetase deficiency (ASNSD) is a rare autosomal recessive neurometabolic disorder associated with microcephaly, severe developmental impairment, epilepsy, and progressive cerebral atrophy. Reduced cerebrospinal fluid (CSF) asparagine has been proposed as a supportive biochemical marker, but the extent to which it provides…

The Neurotypical Assumption in Consumer Research: Rethinking Consumer Heterogeneity Through Neurocognitive Diversity.

Dakič P, Faganel ABehavioral sciences (Basel, Switzerland)

Understanding why individuals perceive, interpret, and respond differently to the same environmental stimuli represents one of the central questions in the behavioral sciences. Across the psychology, cognitive science, neuroscience, and behavioral decision research, substantial effort has been devoted to explaining the mechanisms underlying…