An oxidized ribonucleotide 8-oxoGTP drives neuroinflammation and accelerates cognitive decline.

Jin Li; Zhen-He Wang; Jia-Xin Pan; Zhe-Li Jiang; Rui Li; Xu-Fan Gao; Gang Sheng; Zi-Hui Wang; Ya-Qing Ma; Zheng-Lu Wang; Ting Wang; Ran Huan; Lv-Tao Zeng; Wei Zhang; Da-Peng Dai; Ju Cui; Xiao-Yang Zhou; Li-Qun Zhang; Wen Su; Hai-Bo Chen; Guo-Xin Hu; Ruo-Mei Qi; Jian-Ping Cai

doi:10.1126/sciadv.aee0110

SCHEDA SCIENTIFICA2026Altra ricerca

An oxidized ribonucleotide 8-oxoGTP drives neuroinflammation and accelerates cognitive decline.

Jin Li, Zhen-He Wang, Jia-Xin Pan, Zhe-Li Jiang, Rui Li, Xu-Fan Gao, Gang Sheng, Zi-Hui Wang, Ya-Qing Ma, Zheng-Lu Wang, Ting Wang, Ran Huan, Lv-Tao Zeng, Wei Zhang, Da-Peng Dai, Ju Cui, Xiao-Yang Zhou, Li-Qun Zhang, Wen Su, Hai-Bo Chen, Guo-Xin Hu, Ruo-Mei Qi, Jian-Ping Cai

Science advances · 2026

Neuroscienze Psicologia cognitiva

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Parole chiave

AnimalsMiceOxidation-ReductionMicrogliaCognitive DysfunctionNeuroinflammatory DiseasesOxidative StressGuanosine TriphosphateSignal TransductionReactive Oxygen SpeciesAgingNF-kappa Bsrc-Family KinasesGuanine

Come citare questo studio

Jin Li, Zhen-He Wang, Jia-Xin Pan, Zhe-Li Jiang, Rui Li, Xu-Fan Gao, Gang Sheng, Zi-Hui Wang, Ya-Qing Ma, Zheng-Lu Wang, Ting Wang, Ran Huan, Lv-Tao Zeng, Wei Zhang, Da-Peng Dai, Ju Cui, Xiao-Yang Zhou, Li-Qun Zhang, Wen Su, Hai-Bo Chen, Guo-Xin Hu, Ruo-Mei Qi, Jian-Ping Cai. (2026). An oxidized ribonucleotide 8-oxoGTP drives neuroinflammation and accelerates cognitive decline.. Science advances. DOI: 10.1126/sciadv.aee0110

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