The YTHDF proteins modulate Alzheimer's disease-associated brain gene signatures.

Shinya Tasaki; Denis R Avey; Nicola A Kearns; Chunjiang Yu; Sashini De Tissera; Himanshu Vyas; Lin Cheng; Jishu Xu; Artemis Iatrou; Daniel J Flood; Wenlong Li; Lisa L Barnes; Katherine Rothamel; Aliza P Wingo; Thomas S Wingo; Nicholas T Seyfried; Chuan He; Philip L De Jager; Gene W Yeo; Chris Gaiteri; David A Bennett; Yanling Wang

doi:10.1186/s13024-026-00986-6

SCHEDA SCIENTIFICA2026Altra ricerca

The YTHDF proteins modulate Alzheimer's disease-associated brain gene signatures.

Shinya Tasaki, Denis R Avey, Nicola A Kearns, Chunjiang Yu, Sashini De Tissera, Himanshu Vyas, Lin Cheng, Jishu Xu, Artemis Iatrou, Daniel J Flood, Wenlong Li, Lisa L Barnes, Katherine Rothamel, Aliza P Wingo, Thomas S Wingo, Nicholas T Seyfried, Chuan He, Philip L De Jager, Gene W Yeo, Chris Gaiteri, David A Bennett, Yanling Wang

Molecular neurodegeneration · 2026

Neuroscienze

Abstract e pubblicazione originale

L’abstract è consultabile nella fonte originale. Non viene ripubblicato qui perché non risulta verificata una licenza compatibile.

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Parole chiave

Alzheimer DiseaseHumansBrainRNA-Binding ProteinsTranscriptomeNerve Tissue ProteinsAlzheimer's diseaseCRISPR knockoutCognitive declineCortical organoidsEpitranscriptomicsGene expression signaturesMachine learningPost-transcriptional regulationSmall-molecule YTHDF inhibitioneCLIP-seq

Come citare questo studio

Shinya Tasaki, Denis R Avey, Nicola A Kearns, Chunjiang Yu, Sashini De Tissera, Himanshu Vyas, Lin Cheng, Jishu Xu, Artemis Iatrou, Daniel J Flood, Wenlong Li, Lisa L Barnes, Katherine Rothamel, Aliza P Wingo, Thomas S Wingo, Nicholas T Seyfried, Chuan He, Philip L De Jager, Gene W Yeo, Chris Gaiteri, David A Bennett, Yanling Wang. (2026). The YTHDF proteins modulate Alzheimer's disease-associated brain gene signatures.. Molecular neurodegeneration. DOI: 10.1186/s13024-026-00986-6

Consulta la pubblicazione originale ↗