Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer's disease from amyotrophic lateral sclerosis.

Samir Abu-Rumeileh; Henning Großkopf; Arthur Guthknecht; Alexander Mensch; Dirk Osterloh; Antonia Ratti; Julian Conrad; Caroline Stapf; Julia Krippner; Patrick Oeckl; Gisela Stoltenburg-Didinger; Alessio Maranzano; Petra Steinacker; Christopher M Weise; Lorenzo Barba; Lucio D'Anna; Hans-Wolfgang Klafki; Jens Wiltfang; Vincenzo Silani; Lutz Froelich; Nicola Ticozzi; Lucrezia Hausner; Dietmar Rudolf Thal; Jochen Hans Weishaupt; Ingolf Lachmann; Federico Verde; Markus Otto

doi:10.1038/s41467-026-78390-3

SCHEDA SCIENTIFICA2026Altra ricerca

Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer's disease from amyotrophic lateral sclerosis.

Samir Abu-Rumeileh, Henning Großkopf, Arthur Guthknecht, Alexander Mensch, Dirk Osterloh, Antonia Ratti, Julian Conrad, Caroline Stapf, Julia Krippner, Patrick Oeckl, Gisela Stoltenburg-Didinger, Alessio Maranzano, Petra Steinacker, Christopher M Weise, Lorenzo Barba, Lucio D'Anna, Hans-Wolfgang Klafki, Jens Wiltfang, Vincenzo Silani, Lutz Froelich, Nicola Ticozzi, Lucrezia Hausner, Dietmar Rudolf Thal, Jochen Hans Weishaupt, Ingolf Lachmann, Federico Verde, Markus Otto

Nature communications · 2026

Neuroscienze

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Parole chiave

HumansAmyotrophic Lateral Sclerosistau ProteinsAlzheimer DiseaseFemaleProtein IsoformsMaleBiomarkersBrainAgedPhosphorylationSpinal CordMass SpectrometryMiddle AgedDiagnosis, DifferentialAged, 80 and overImmunoprecipitationCase-Control Studies

Come citare questo studio

Samir Abu-Rumeileh, Henning Großkopf, Arthur Guthknecht, Alexander Mensch, Dirk Osterloh, Antonia Ratti, Julian Conrad, Caroline Stapf, Julia Krippner, Patrick Oeckl, Gisela Stoltenburg-Didinger, Alessio Maranzano, Petra Steinacker, Christopher M Weise, Lorenzo Barba, Lucio D'Anna, Hans-Wolfgang Klafki, Jens Wiltfang, Vincenzo Silani, Lutz Froelich, Nicola Ticozzi, Lucrezia Hausner, Dietmar Rudolf Thal, Jochen Hans Weishaupt, Ingolf Lachmann, Federico Verde, Markus Otto. (2026). Tau isoform mapping across tissues and biofluids reveals a signature distinguishing Alzheimer's disease from amyotrophic lateral sclerosis.. Nature communications. DOI: 10.1038/s41467-026-78390-3

Consulta la pubblicazione originale ↗