Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.

Annalise Schweickart; Richa Batra; Kevin Huynh; Collette Blach; Alexandra Kueider-Paisley; Joseph S Reddy; David A Bennett; Peter J Meikle; Bin Zhang; Philip L De Jager; Laura Heath; Jaclyn Beck; Jo Scanlan; Nicholas T Seyfried; Dennis W Dickson; Nilüfer Ertekin-Taner; Alzheimer's Disease Metabolomics Consortium; Rima Kaddurah-Daouk; Matthias Arnold; Jan Krumsiek

doi:10.1002/alz.71690

SCHEDA SCIENTIFICA2026Altra ricerca

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.

Annalise Schweickart, Richa Batra, Kevin Huynh, Collette Blach, Alexandra Kueider-Paisley, Joseph S Reddy, David A Bennett, Peter J Meikle, Bin Zhang, Philip L De Jager, Laura Heath, Jaclyn Beck, Jo Scanlan, Nicholas T Seyfried, Dennis W Dickson, Nilüfer Ertekin-Taner, Alzheimer's Disease Metabolomics Consortium, Rima Kaddurah-Daouk, Matthias Arnold, Jan Krumsiek

Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026

Neuroscienze

Abstract e pubblicazione originale

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Parole chiave

AgedAged, 80 and overFemaleHumansMaleAlzheimer DiseaseBlack or African AmericanBrainCeramidesHispanic or LatinoMetabolomicsSphingolipidstau ProteinsWhiteAMP‐AD Diverse CohortsAPOE4Alzheimer's diseaseBraak stageLipid metabolismacetylcholinebrain metabolomicsceramidedipeptidesdorsolateral prefrontal cortexethnoracial differencesmetabolic heterogeneitymultiethnic cohortneurodegenerationpopulation health disparitiespost‐mortem brainprecision therapeuticssphingolipid metabolismtau pathologytricarboxylic acid cycle

Come citare questo studio

Annalise Schweickart, Richa Batra, Kevin Huynh, Collette Blach, Alexandra Kueider-Paisley, Joseph S Reddy, David A Bennett, Peter J Meikle, Bin Zhang, Philip L De Jager, Laura Heath, Jaclyn Beck, Jo Scanlan, Nicholas T Seyfried, Dennis W Dickson, Nilüfer Ertekin-Taner, Alzheimer's Disease Metabolomics Consortium, Rima Kaddurah-Daouk, Matthias Arnold, Jan Krumsiek. (2026). Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue.. Alzheimer's & dementia : the journal of the Alzheimer's Association. DOI: 10.1002/alz.71690

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