Somatic mutations reveal the ontogeny of microglia in human ageing.

Julia A Belk; Yaowen Zhang; Emily E Reilly; Quanming Shi; Daniel Dan Liu; Nicole Womack-Gambrel; Maarten van der Linde; Lisa Ma; Debasmita Paul; Alejandro Medina Enciso; Raja Kalluru; Jacob Weiss; Rui Li; Anna E Eastman; Chunfang Zhu; Arnav Chakravarthy; Syed Bukhari; Dipabarna Bhattacharya; Suyash Raj; Daniel Richard; Simone Brioschi; Matthew R Chrostek; Daniel C Nachun; Christopher M Arends; Jayakrishnan Gopakumar; Isak W Tengesdal; Ademar Bynum; Shaneice Mitchell; Katalin Sandor; Wenxi Zhang; Badri N Vardarajan; Inma Cobos; Donald E Born; Robert B West; Anne Brunet; Marco Colonna; Krishna L Bharani; Hannes Vogel; Thomas J Montine; Caitlin S Latimer; Irving L Weissman; Magdalena Matusiak; Jody E Hooper; C Dirk Keene; Howard Y Chang; Siddhartha Jaiswal

doi:10.1038/s41586-026-10939-0

SCHEDA SCIENTIFICA2026Altra ricerca

Somatic mutations reveal the ontogeny of microglia in human ageing.

Julia A Belk, Yaowen Zhang, Emily E Reilly, Quanming Shi, Daniel Dan Liu, Nicole Womack-Gambrel, Maarten van der Linde, Lisa Ma, Debasmita Paul, Alejandro Medina Enciso, Raja Kalluru, Jacob Weiss, Rui Li, Anna E Eastman, Chunfang Zhu, Arnav Chakravarthy, Syed Bukhari, Dipabarna Bhattacharya, Suyash Raj, Daniel Richard, Simone Brioschi, Matthew R Chrostek, Daniel C Nachun, Christopher M Arends, Jayakrishnan Gopakumar, Isak W Tengesdal, Ademar Bynum, Shaneice Mitchell, Katalin Sandor, Wenxi Zhang, Badri N Vardarajan, Inma Cobos, Donald E Born, Robert B West, Anne Brunet, Marco Colonna, Krishna L Bharani, Hannes Vogel, Thomas J Montine, Caitlin S Latimer, Irving L Weissman, Magdalena Matusiak, Jody E Hooper, C Dirk Keene, Howard Y Chang, Siddhartha Jaiswal

Nature · 2026

Neuroscienze

Abstract e pubblicazione originale

L’abstract è consultabile nella fonte originale. Non viene ripubblicato qui perché non risulta verificata una licenza compatibile.

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Parole chiave

AgedAged, 80 and overAnimalsFemaleHumansMaleMiceAgingAlzheimer DiseaseBone Marrow CellsBrainCell LineageClonal HematopoiesisClone CellsDNA, MitochondrialMicrogliaMutationMyeloid CellsSingle-Cell Analysis

Come citare questo studio

Julia A Belk, Yaowen Zhang, Emily E Reilly, Quanming Shi, Daniel Dan Liu, Nicole Womack-Gambrel, Maarten van der Linde, Lisa Ma, Debasmita Paul, Alejandro Medina Enciso, Raja Kalluru, Jacob Weiss, Rui Li, Anna E Eastman, Chunfang Zhu, Arnav Chakravarthy, Syed Bukhari, Dipabarna Bhattacharya, Suyash Raj, Daniel Richard, Simone Brioschi, Matthew R Chrostek, Daniel C Nachun, Christopher M Arends, Jayakrishnan Gopakumar, Isak W Tengesdal, Ademar Bynum, Shaneice Mitchell, Katalin Sandor, Wenxi Zhang, Badri N Vardarajan, Inma Cobos, Donald E Born, Robert B West, Anne Brunet, Marco Colonna, Krishna L Bharani, Hannes Vogel, Thomas J Montine, Caitlin S Latimer, Irving L Weissman, Magdalena Matusiak, Jody E Hooper, C Dirk Keene, Howard Y Chang, Siddhartha Jaiswal. (2026). Somatic mutations reveal the ontogeny of microglia in human ageing.. Nature. DOI: 10.1038/s41586-026-10939-0

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