Single-nucleus transcriptomics reveals disrupted pathways in the prefrontal cortex of Scn2a-deficient mice.

Ye-Eun Yoo; Zaiyang Zhang; Purba Mandal; Zhengkuan Tang; Jingliang Zhang; Xiaoling Chen; Morgan Robinson; Muriel Eaton; Brody Deming; Manasi Halurkar; Harish Kothandaraman; Luke C Dabin; Boyu Jiang; Hongyu Gao; Chongli Yuan; Nadia Lanman; Yunlong Liu; Jungsu Kim; Priyanka Baloni; Yang Yang

doi:10.1038/s41398-026-04348-0

SCHEDA SCIENTIFICA2026Altra ricerca

Single-nucleus transcriptomics reveals disrupted pathways in the prefrontal cortex of Scn2a-deficient mice.

Ye-Eun Yoo, Zaiyang Zhang, Purba Mandal, Zhengkuan Tang, Jingliang Zhang, Xiaoling Chen, Morgan Robinson, Muriel Eaton, Brody Deming, Manasi Halurkar, Harish Kothandaraman, Luke C Dabin, Boyu Jiang, Hongyu Gao, Chongli Yuan, Nadia Lanman, Yunlong Liu, Jungsu Kim, Priyanka Baloni, Yang Yang

Translational psychiatry · 2026

Psicologia clinica Neuroscienze

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Parole chiave

AnimalsPrefrontal CortexNAV1.2 Voltage-Gated Sodium ChannelMiceTranscriptomeAutism Spectrum DisorderDisease Models, AnimalGABAergic NeuronsSingle-Cell Gene Expression AnalysisMaleEpilepsyMice, Knockout

Come citare questo studio

Ye-Eun Yoo, Zaiyang Zhang, Purba Mandal, Zhengkuan Tang, Jingliang Zhang, Xiaoling Chen, Morgan Robinson, Muriel Eaton, Brody Deming, Manasi Halurkar, Harish Kothandaraman, Luke C Dabin, Boyu Jiang, Hongyu Gao, Chongli Yuan, Nadia Lanman, Yunlong Liu, Jungsu Kim, Priyanka Baloni, Yang Yang. (2026). Single-nucleus transcriptomics reveals disrupted pathways in the prefrontal cortex of Scn2a-deficient mice.. Translational psychiatry. DOI: 10.1038/s41398-026-04348-0

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