Repositioning of polyubiquitin alters the pathologic tau filament structure.

Ryohei Watanabe; Benjamin C Creekmore; Nabil F Darwich; Courtney L Smith; Hong Xu; Angelina Baltazar; Sacha Salphati; Lakshmi Changolkar; Kevt'her Hoxha; Bin Zhang; Caroline M O'Rourke; George M Burslem; Virginia M-Y Lee; Yi-Wei Chang; Edward B Lee

doi:10.1038/s41594-026-01879-4

SCHEDA SCIENTIFICA2026Altra ricerca

Repositioning of polyubiquitin alters the pathologic tau filament structure.

Ryohei Watanabe, Benjamin C Creekmore, Nabil F Darwich, Courtney L Smith, Hong Xu, Angelina Baltazar, Sacha Salphati, Lakshmi Changolkar, Kevt'her Hoxha, Bin Zhang, Caroline M O'Rourke, George M Burslem, Virginia M-Y Lee, Yi-Wei Chang, Edward B Lee

Nature structural & molecular biology · 2026

Neuroscienze

Abstract e pubblicazione originale

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Parole chiave

tau ProteinsAnimalsHumansCryoelectron MicroscopyPolyubiquitinTauopathiesMiceAlzheimer DiseaseProtein Processing, Post-TranslationalBrain

Come citare questo studio

Ryohei Watanabe, Benjamin C Creekmore, Nabil F Darwich, Courtney L Smith, Hong Xu, Angelina Baltazar, Sacha Salphati, Lakshmi Changolkar, Kevt'her Hoxha, Bin Zhang, Caroline M O'Rourke, George M Burslem, Virginia M-Y Lee, Yi-Wei Chang, Edward B Lee. (2026). Repositioning of polyubiquitin alters the pathologic tau filament structure.. Nature structural & molecular biology. DOI: 10.1038/s41594-026-01879-4

Consulta la pubblicazione originale ↗