Novel hydrazone-linked pyridin-1-ium salts as multi-targeted agents for Alzheimer's disease: design, synthesis, in vitro and in silico studies.
Bioorganic & medicinal chemistry · 2026
Abstract e pubblicazione originale
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Leggi nella fonte originale ↗Parole chiave
Alzheimer DiseaseDrug DesignStructure-Activity RelationshipCholinesterase InhibitorsHumansAmyloid Precursor Protein SecretasesHydrazonesAcetylcholinesteraseMolecular Docking SimulationAspartic Acid EndopeptidasesMolecular StructureSaltsDose-Response Relationship, DrugPyridinesAnti-Alzheimer's agentsHydrazoneMolecular dynamicsMulti-targetedPyridin-1-ium
Come citare questo studio
Hoang Tran, Le Quoc Tien, Tran Thi Thu Hien, Tran Xuan Vinh, Vu Minh Duc, Tran Thi Thanh Xuan, Nguyen Thi Hien, Tran Vu Thuy Linh, Nguyen Quoc Thang, Pham Thi Ngoc Minh, Tiep K Nguyen, Thi-Huyen-Trang Nguyen, Duc-Vinh Pham, Shuai Wang, Phuong-Thao Tran. (2026). Novel hydrazone-linked pyridin-1-ium salts as multi-targeted agents for Alzheimer's disease: design, synthesis, in vitro and in silico studies.. Bioorganic & medicinal chemistry. DOI: 10.1016/j.bmc.2026.118778
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