Impact of an early extended rehabilitation programme combining individually tailored nutrition and physical activity on patient outcomes after invasive mechanical ventilation and vasopressor therapy in the ICU: design and conduct of a multicentre, randomised, controlled, open-label, assessor-blinded trial (NUTRIREA-4).
BMJ open · 2026
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Jean Reignier, Soraya Benguerfi, Emeline Corbin, Diane Maugars, Ronan Thibault, Adam Jirka, Thomas Cattagni, Antoine Nordez, Laurent Argaud, Julio Badie, Maxime Bertrand, Alexandra Beurton, Matthieu Boiffier, Nicolae-Vlad Botoc, Claire Bourel, Anne-Astrid Bourion, Akli Chermak, Michael Darmon, Matthieu Debarre, Agathe Delbove, Maxime Desgrouas, Jérôme Devaquet, Louis-Marie Galerneau, Quentin Georges, Vivien Guillotin, Laurent Guérin, Christophe Henry, Jean-Etienne Herbrecht, Samir Jaber, Béatrice La Combe, Laurent Lainé, Fabien Lambiotte, Mickael Landais, Julien Maizel, Stéphanie Malaquin, Thomas Maldiney, Virginie Maxime, Emmanuelle Mercier, Hamid Merdji, Jean-Paul Mira, Elise Morawiec, Damien Muller, Olivier Nigeon, Thibaut Noel, Marc Pierrot, Gael Piton, Gaetan Plantefeve, Jean-Pierre Quenot, Jean Philippe Rigaud, Marion Rougon, Clément Saccheri, Ghada Sboui, Daniel Silva, Bertrand Souweine, Jean Marc Tadie, Fabienne Tamion, Guillaume Thiery, Thierry Vanderlinden, Isabelle Vinatier, Robin Souron, Amélie Le Gouge. (2026). Impact of an early extended rehabilitation programme combining individually tailored nutrition and physical activity on patient outcomes after invasive mechanical ventilation and vasopressor therapy in the ICU: design and conduct of a multicentre, randomised, controlled, open-label, assessor-blinded trial (NUTRIREA-4).. BMJ open. DOI: 10.1136/bmjopen-2026-127985
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