HIF-1 plays a dual regulatory role in hippocampal neuronal PANoptosis in Alzheimer's disease via the HK2/VDAC1/NLRP3 axis and RIPK3 signaling.
Pharmacological research · 2026
Abstract e pubblicazione originale
L’abstract è consultabile nella fonte originale. Non viene ripubblicato qui perché non risulta verificata una licenza compatibile.
Leggi nella fonte originale ↗Parole chiave
AnimalsHippocampusAlzheimer DiseaseSignal TransductionNeuronsReceptor-Interacting Protein Serine-Threonine KinasesHypoxia-Inducible Factor 1, alpha SubunitSemaglutideVoltage-Dependent Anion Channel 1MaleAmyloid beta-PeptidesHumansMiceMice, Inbred C57BLGlucagon-Like Peptide-1 ReceptorAlzheimer’s diseaseDouble-edged sword effectHIF-1 signaling pathwayHippocampal neuronal PANoptosis
Come citare questo studio
Siqi Wang, Laixi Luo, Xilin Jiang, Jun Hai, Weilin Liu, Xianhui Zhou, Ying Li, Lichao Yang. (2026). HIF-1 plays a dual regulatory role in hippocampal neuronal PANoptosis in Alzheimer's disease via the HK2/VDAC1/NLRP3 axis and RIPK3 signaling.. Pharmacological research. DOI: 10.1016/j.phrs.2026.108440
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