Discovery of a BBB-Penetrant Lanosterol Derivative as an Aβ Aggregation Inhibitor for Alzheimer's Disease.

Baichen Xiong; Tengfei Zhen; Xinhai Wang; Weiting Zhang; Zhiqiang Wang; Mingkang Ma; Xiaoxue Bai; Jiawei Zhu; Na Zheng; Yuqing Wei; Mengxiao Chen; Pengkun Sun; Bingbing Lv; Chenyu Zhang; Ziyu Cao; Yuanyuan Wang; Xianshu Bai; Wenyuan Liu; Chaojun Wang; Yue Wu; Yao Chen; Haopeng Sun

doi:10.1021/acs.jmedchem.6c02238

SCHEDA SCIENTIFICA2026Altra ricerca

Discovery of a BBB-Penetrant Lanosterol Derivative as an Aβ Aggregation Inhibitor for Alzheimer's Disease.

Baichen Xiong, Tengfei Zhen, Xinhai Wang, Weiting Zhang, Zhiqiang Wang, Mingkang Ma, Xiaoxue Bai, Jiawei Zhu, Na Zheng, Yuqing Wei, Mengxiao Chen, Pengkun Sun, Bingbing Lv, Chenyu Zhang, Ziyu Cao, Yuanyuan Wang, Xianshu Bai, Wenyuan Liu, Chaojun Wang, Yue Wu, Yao Chen, Haopeng Sun

Journal of medicinal chemistry · 2026

Psicologia cognitiva

Abstract e pubblicazione originale

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Parole chiave

Alzheimer DiseaseAnimalsAmyloid beta-PeptidesLanosterolMiceHumansBlood-Brain BarrierStructure-Activity RelationshipDrug DiscoveryProtein AggregatesMaleAlzheimer’s diseaseCNS drug-like propertieslanosterol derivativeAβ aggregation inhibitor

Come citare questo studio

Baichen Xiong, Tengfei Zhen, Xinhai Wang, Weiting Zhang, Zhiqiang Wang, Mingkang Ma, Xiaoxue Bai, Jiawei Zhu, Na Zheng, Yuqing Wei, Mengxiao Chen, Pengkun Sun, Bingbing Lv, Chenyu Zhang, Ziyu Cao, Yuanyuan Wang, Xianshu Bai, Wenyuan Liu, Chaojun Wang, Yue Wu, Yao Chen, Haopeng Sun. (2026). Discovery of a BBB-Penetrant Lanosterol Derivative as an Aβ Aggregation Inhibitor for Alzheimer's Disease.. Journal of medicinal chemistry. DOI: 10.1021/acs.jmedchem.6c02238

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