De novo formation of familial Alzheimer's disease-relevant Aβ strains occurs exclusively in the human brain.

Alison Mao; Alejandro Ruiz-Riquelme; Marim M Barghash; Nicholas R G Silver; Heather H C Lau; Erica Stuart; Silvia Zampar; Dag Sehlin; Stina Syvänen; Michael S Pollanen; K Peter R Nilsson; Caroline Graff; Martin Ingelsson; Joel C Watts

doi:10.1186/s40478-026-02390-z

SCHEDA SCIENTIFICA2026Altra ricerca

De novo formation of familial Alzheimer's disease-relevant Aβ strains occurs exclusively in the human brain.

Alison Mao, Alejandro Ruiz-Riquelme, Marim M Barghash, Nicholas R G Silver, Heather H C Lau, Erica Stuart, Silvia Zampar, Dag Sehlin, Stina Syvänen, Michael S Pollanen, K Peter R Nilsson, Caroline Graff, Martin Ingelsson, Joel C Watts

Acta neuropathologica communications · 2026

Neuroscienze

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Parole chiave

AnimalsHumansAlzheimer DiseaseBrainMice, TransgenicAmyloid beta-Protein PrecursorAmyloid beta-PeptidesMutationMiceFemaleMalePlaque, AmyloidAgedDisease Models, AnimalAlzheimer’s diseaseAmyloidKnock-in miceProtein aggregationSeedingStrain

Come citare questo studio

Alison Mao, Alejandro Ruiz-Riquelme, Marim M Barghash, Nicholas R G Silver, Heather H C Lau, Erica Stuart, Silvia Zampar, Dag Sehlin, Stina Syvänen, Michael S Pollanen, K Peter R Nilsson, Caroline Graff, Martin Ingelsson, Joel C Watts. (2026). De novo formation of familial Alzheimer's disease-relevant Aβ strains occurs exclusively in the human brain.. Acta neuropathologica communications. DOI: 10.1186/s40478-026-02390-z

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