Current landscape and future perspectives of small-molecule therapeutics for Huntington's disease: From rational design to clinical translation.

Yitian Jiang; Xinyi Chen; Zhaoxin Xu; Xiao Chen; Qinjie Wang; Junying Ma; Xiyang Wu; Guangyao Deng; Simeng Li; Haopeng Sun; Yao Chen

doi:10.1016/j.ejmech.2026.119224

SCHEDA SCIENTIFICA2026Altra ricerca

Current landscape and future perspectives of small-molecule therapeutics for Huntington's disease: From rational design to clinical translation.

Yitian Jiang, Xinyi Chen, Zhaoxin Xu, Xiao Chen, Qinjie Wang, Junying Ma, Xiyang Wu, Guangyao Deng, Simeng Li, Haopeng Sun, Yao Chen

European journal of medicinal chemistry · 2026

Psicologia clinica Psicoterapia Psicologia dello sviluppo

Abstract e pubblicazione originale

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Parole chiave

Huntington DiseaseHumansSmall Molecule LibrariesDrug DesignAnimalsNeuroprotective AgentsHuntingtin ProteinMolecular StructureHuntington's diseaseMutant huntingtin and small molecules

Come citare questo studio

Yitian Jiang, Xinyi Chen, Zhaoxin Xu, Xiao Chen, Qinjie Wang, Junying Ma, Xiyang Wu, Guangyao Deng, Simeng Li, Haopeng Sun, Yao Chen. (2026). Current landscape and future perspectives of small-molecule therapeutics for Huntington's disease: From rational design to clinical translation.. European journal of medicinal chemistry. DOI: 10.1016/j.ejmech.2026.119224

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