Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities.

Raleigh M Linville; Benjamin T James; Kyriaki Galani; Li-Lun Ho; Jung Hoon Shin; Esaria Oliver; Stuart B Fass; James C Cameron; Brent E Fitzwalter; Roland Bock; Erin M Murray; Mathilde Louçã; Oluwamayowa Oke; Charlotte Wang; Erica Engelberg-Cook; Michael DeTure; Vanessa Farrell; Sergio Sebastian Pineda; Suphinya Sathitloetsakun; Xinyue Liang; Bertha Madras; Dennis W Dickson; Deborah C Mash; Gustavo Turecki; Vanessa C Wheeler; Veronica A Alvarez; Dana Gabuzda; Manolis Kellis; Myriam Heiman

doi:10.1016/j.cell.2026.08.006

SCHEDA SCIENTIFICA2026Altra ricerca

Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities.

Raleigh M Linville, Benjamin T James, Kyriaki Galani, Li-Lun Ho, Jung Hoon Shin, Esaria Oliver, Stuart B Fass, James C Cameron, Brent E Fitzwalter, Roland Bock, Erin M Murray, Mathilde Louçã, Oluwamayowa Oke, Charlotte Wang, Erica Engelberg-Cook, Michael DeTure, Vanessa Farrell, Sergio Sebastian Pineda, Suphinya Sathitloetsakun, Xinyue Liang, Bertha Madras, Dennis W Dickson, Deborah C Mash, Gustavo Turecki, Vanessa C Wheeler, Veronica A Alvarez, Dana Gabuzda, Manolis Kellis, Myriam Heiman

Cell · 2026

Neuroscienze

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Parole chiave

AnimalsHumansHuntington DiseaseMiceCorpus StriatumSingle-Cell AnalysisNeuronsMedium Spiny NeuronsMaleSingle-Cell Gene Expression AnalysisTranscriptomeReceptors, OpioidSpecies SpecificityGenome-Wide Association StudyTrinucleotide Repeat ExpansionHuntington’s diseaseantipsychoticscross-species comparisonmedium spiny neuronsopioid receptorsrepeat instabilitysingle-cell RNA sequencingspatial transcriptomicsstriatum

Come citare questo studio

Raleigh M Linville, Benjamin T James, Kyriaki Galani, Li-Lun Ho, Jung Hoon Shin, Esaria Oliver, Stuart B Fass, James C Cameron, Brent E Fitzwalter, Roland Bock, Erin M Murray, Mathilde Louçã, Oluwamayowa Oke, Charlotte Wang, Erica Engelberg-Cook, Michael DeTure, Vanessa Farrell, Sergio Sebastian Pineda, Suphinya Sathitloetsakun, Xinyue Liang, Bertha Madras, Dennis W Dickson, Deborah C Mash, Gustavo Turecki, Vanessa C Wheeler, Veronica A Alvarez, Dana Gabuzda, Manolis Kellis, Myriam Heiman. (2026). Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities.. Cell. DOI: 10.1016/j.cell.2026.08.006

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