Computational modeling and preclinical evaluation support targeting somatic instability for Huntington's disease treatment.

Bryan P Simpson; Paul T Ranum; David E Leib; Luis Tecedor; Ryan C Giovenco; Icnelia Huerta-Ocampo; Amiel A Hundley; Noah Smith; Christopher M Fluta; Christopher P Cali; Jamie Benoit; Jenna C Soper; John Connelly; George J Yohrling; P Peter Ghoroghchian; Jang-Ho J Cha; Beverly L Davidson

doi:10.1038/s41467-026-78769-2

SCHEDA SCIENTIFICA2026Altra ricerca

Computational modeling and preclinical evaluation support targeting somatic instability for Huntington's disease treatment.

Bryan P Simpson, Paul T Ranum, David E Leib, Luis Tecedor, Ryan C Giovenco, Icnelia Huerta-Ocampo, Amiel A Hundley, Noah Smith, Christopher M Fluta, Christopher P Cali, Jamie Benoit, Jenna C Soper, John Connelly, George J Yohrling, P Peter Ghoroghchian, Jang-Ho J Cha, Beverly L Davidson

Nature communications · 2026

Psicologia clinica Psicoterapia

Abstract e pubblicazione originale

L’abstract è consultabile nella fonte originale. Non viene ripubblicato qui perché non risulta verificata una licenza compatibile.

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Parole chiave

AnimalsHuntington DiseaseHumansMiceDependovirusComputer SimulationDisease Models, AnimalMedium Spiny NeuronsGenetic TherapyMicroRNAsTrinucleotide Repeat ExpansionGenetic VectorsRNA, MessengerFemaleMale

Come citare questo studio

Bryan P Simpson, Paul T Ranum, David E Leib, Luis Tecedor, Ryan C Giovenco, Icnelia Huerta-Ocampo, Amiel A Hundley, Noah Smith, Christopher M Fluta, Christopher P Cali, Jamie Benoit, Jenna C Soper, John Connelly, George J Yohrling, P Peter Ghoroghchian, Jang-Ho J Cha, Beverly L Davidson. (2026). Computational modeling and preclinical evaluation support targeting somatic instability for Huntington's disease treatment.. Nature communications. DOI: 10.1038/s41467-026-78769-2

Consulta la pubblicazione originale ↗