Cell-based polygenic risk scores predict clinical progression and prioritize network-based therapeutic targets in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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HumansAlzheimer DiseaseGenetic Risk ScoreDisease ProgressionFemaleApolipoproteins EMaleAgedAstrocytesInduced Pluripotent Stem CellsGenetic Predisposition to DiseaseAlzheimer's diseasePageRank algorithmcell‐based polygenic risk scorecell‐level co‐expression networkcognitive performancedrug repurposingpatient stratificationprecision medicine
Come citare questo studio
Nathan Sahelijo, Priya Rajagopalan, Lu Qian, Rufuto Rahman, Daniel Goldstein, Sophia I Thomopoulos, David A Bennett, Lindsay A Farrer, Thor D Stein, Li Shen, Heng Huang, Kwangsik Nho, Andrew J Saykin, Christos Davatzikos, Paul M Thompson, Julia Tcw, Gyungah R Jun. (2026). Cell-based polygenic risk scores predict clinical progression and prioritize network-based therapeutic targets in Alzheimer's disease.. Alzheimer's & dementia : the journal of the Alzheimer's Association. DOI: 10.1002/alz.71895
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