Brain Penetration Optimization and Anti-neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer's Disease.

Huanhua Chen; Xinzhu Li; Siyuan Liu; Zhenshu Li; Wenjie Liu; Xinhui Ye; Fangyuan Zheng; Xi Zeng; Junjie Lin; Aizhu Yang; Xinpeng Wang; Mengyu Ren; Xudong Gao; Zihua Xu; Jingming Jia; Qingchun Zhao

doi:10.1021/acs.jmedchem.6c01681

SCHEDA SCIENTIFICA2026Altra ricerca

Brain Penetration Optimization and Anti-neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer's Disease.

Huanhua Chen, Xinzhu Li, Siyuan Liu, Zhenshu Li, Wenjie Liu, Xinhui Ye, Fangyuan Zheng, Xi Zeng, Junjie Lin, Aizhu Yang, Xinpeng Wang, Mengyu Ren, Xudong Gao, Zihua Xu, Jingming Jia, Qingchun Zhao

Journal of medicinal chemistry · 2026

Psicoterapia Neuroscienze

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Parole chiave

Alzheimer DiseaseAnimalsDyrk KinasesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesBrainQuinazolinesMiceHumansProtein Kinase InhibitorsMice, TransgenicStructure-Activity RelationshipNeuroinflammatory DiseasesTyrosine Kinase InhibitorsRatsMale

Come citare questo studio

Huanhua Chen, Xinzhu Li, Siyuan Liu, Zhenshu Li, Wenjie Liu, Xinhui Ye, Fangyuan Zheng, Xi Zeng, Junjie Lin, Aizhu Yang, Xinpeng Wang, Mengyu Ren, Xudong Gao, Zihua Xu, Jingming Jia, Qingchun Zhao. (2026). Brain Penetration Optimization and Anti-neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer's Disease.. Journal of medicinal chemistry. DOI: 10.1021/acs.jmedchem.6c01681

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