Anti-HDGFL2 cryptic protein antibodies provide a sensitive readout of TDP-43 pathology and clinical disease features.

Kathryn J Citrano; Vidhya Bharathi Maheswari Jawahar; Madison M Reeves; Leonardo Petrucelli; Yari Carlomagno; Mei Yue; Jorge Alaiz Noya; Lillian M Daughrity; Raul Baena Tomé; Karen Jansen-West; Bailey Rawlinson; Michael DeTure; Erica Engelberg-Cook; Alpana Singh; Neill R Graff-Radford; Gregory S Day; Bradley F Boeve; Adam L Boxer; David S Knopman; Keith A Josephs; Ronald C Petersen; Björn Oskarsson; Nicholas J Ashton; Dennis W Dickson; Tania F Gendron; Mercedes Prudencio; Yong-Jie Zhang; Leonard Petrucelli

doi:10.1016/j.xcrm.2026.103105

SCHEDA SCIENTIFICA2026Altra ricerca

Anti-HDGFL2 cryptic protein antibodies provide a sensitive readout of TDP-43 pathology and clinical disease features.

Kathryn J Citrano, Vidhya Bharathi Maheswari Jawahar, Madison M Reeves, Leonardo Petrucelli, Yari Carlomagno, Mei Yue, Jorge Alaiz Noya, Lillian M Daughrity, Raul Baena Tomé, Karen Jansen-West, Bailey Rawlinson, Michael DeTure, Erica Engelberg-Cook, Alpana Singh, Neill R Graff-Radford, Gregory S Day, Bradley F Boeve, Adam L Boxer, David S Knopman, Keith A Josephs, Ronald C Petersen, Björn Oskarsson, Nicholas J Ashton, Dennis W Dickson, Tania F Gendron, Mercedes Prudencio, Yong-Jie Zhang, Leonard Petrucelli

Cell reports. Medicine · 2026

Psicologia clinica

Abstract e pubblicazione originale

L’abstract è consultabile nella fonte originale. Non viene ripubblicato qui perché non risulta verificata una licenza compatibile.

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Parole chiave

HumansDNA-Binding ProteinsAnimalsFrontotemporal Lobar DegenerationAntibodiesAmyotrophic Lateral SclerosisNeuronsHDGFL2-CETDP-43amyotrophic lateral sclerosiscryptic exonfrontotemporal lobar degenerationmotor neuron disease

Come citare questo studio

Kathryn J Citrano, Vidhya Bharathi Maheswari Jawahar, Madison M Reeves, Leonardo Petrucelli, Yari Carlomagno, Mei Yue, Jorge Alaiz Noya, Lillian M Daughrity, Raul Baena Tomé, Karen Jansen-West, Bailey Rawlinson, Michael DeTure, Erica Engelberg-Cook, Alpana Singh, Neill R Graff-Radford, Gregory S Day, Bradley F Boeve, Adam L Boxer, David S Knopman, Keith A Josephs, Ronald C Petersen, Björn Oskarsson, Nicholas J Ashton, Dennis W Dickson, Tania F Gendron, Mercedes Prudencio, Yong-Jie Zhang, Leonard Petrucelli. (2026). Anti-HDGFL2 cryptic protein antibodies provide a sensitive readout of TDP-43 pathology and clinical disease features.. Cell reports. Medicine. DOI: 10.1016/j.xcrm.2026.103105

Consulta la pubblicazione originale ↗