Adult ADHD, PARK2 copy number variations and the blood-brain barrier: Culture duration-dependent metabolic alterations in human induced pluripotent stem cell-derived in vitro models.
Fluids and barriers of the CNS · 2026
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HumansInduced Pluripotent Stem CellsDNA Copy Number VariationsAdultBlood-Brain BarrierUbiquitin-Protein LigasesAttention Deficit Disorder with HyperactivityEndothelial CellsMitochondriaMaleCells, CulturedAttention-deficit/hyperactivity disorderBlood-brain barrierCellular bioenergeticsCopy number variationEndothelial cellsInduced pluripotent stem cellsMitochondrial dysfunctionMitochondrial membrane potentialPARK2Reactive oxygen species
Come citare questo studio
Markus Glaser, Liane Dieterich, Laura Ceslik, Zora Schickardt, Sabine Gätzner, Luisa Schmitt, Heike Oberwinkler, Jasmin Reining, Mike Friedrich, Katherina Hemmen, Werner Schmitz, Rhiannon Victoria McNeill, Sarah Kittel-Schneider, Antje Appelt-Menzel. (2026). Adult ADHD, PARK2 copy number variations and the blood-brain barrier: Culture duration-dependent metabolic alterations in human induced pluripotent stem cell-derived in vitro models.. Fluids and barriers of the CNS. DOI: 10.1186/s12987-026-00892-5
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