A mechanistic PK/PD model of fentanyl overdose and intranasal naloxone rescue incorporating receptor-level competition.

Jasmin A Hossain; David R Taft; Kevin R Sweeney; Akm Khairuzzaman; Robert A Bellantone

doi:10.1007/s10928-026-10070-7

SCHEDA SCIENTIFICA2026Altra ricerca

A mechanistic PK/PD model of fentanyl overdose and intranasal naloxone rescue incorporating receptor-level competition.

Jasmin A Hossain, David R Taft, Kevin R Sweeney, Akm Khairuzzaman, Robert A Bellantone

Journal of pharmacokinetics and pharmacodynamics · 2026

Psicologia clinica Psicopatologia Neuroscienze

Abstract e pubblicazione originale

L’abstract è consultabile nella fonte originale. Non viene ripubblicato qui perché non risulta verificata una licenza compatibile.

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Parole chiave

NaloxoneHumansFentanylAdministration, IntranasalReceptors, Opioid, muDrug OverdoseModels, BiologicalNarcotic AntagonistsBrainAnalgesics, OpioidFentanyl overdose modelingIntranasal nose-to-brain drug deliveryMechanistic PK/PD simulationMu-opioid receptor occupancyNaloxone PKPDNaloxone rescue

Come citare questo studio

Jasmin A Hossain, David R Taft, Kevin R Sweeney, Akm Khairuzzaman, Robert A Bellantone. (2026). A mechanistic PK/PD model of fentanyl overdose and intranasal naloxone rescue incorporating receptor-level competition.. Journal of pharmacokinetics and pharmacodynamics. DOI: 10.1007/s10928-026-10070-7

Consulta la pubblicazione originale ↗