6 Novembre 2026

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2026Caso clinicoTesto disponibile

Therapeutic drug monitoring-guided management of venlafaxine overdose in an adolescent: a case report.

Michaela Krivošová, Nela Žideková, Zuzana Kubisová et al.Journal of analytical toxicology

This report describes an adolescent with severe venlafaxine intoxication in whom serial therapeutic drug monitoring (TDM) was performed, enabling detailed toxicokinetic characterization throughout the clinical course. The initial plasma concentration of the active venlafaxine moiety was 7800 ng/mL, nearly 20 times the upper…

2026Studio osservazionaleTesto disponibile

Developmental pathways to autism in tuberous sclerosis complex: Evidence from a longitudinal cohort.

Fiona S McEwen, Abigail K Runicles, Holan Liang et al.Epilepsia

The association between autism spectrum disorder (hereafter referred to as autism) and tuberous sclerosis complex (TSC) is well established, yet the developmental pathways linking genetic mutation, cortical pathology, and epilepsy with autism remain unclear. The Tuberous Sclerosis 2000 Study recruited children newly diagnosed…

2026Altra ricercaTesto disponibile

The brain age gap as a predictor of alcohol initiation in adolescence.

H Byrne, R Visontay, E K Devine et al.Developmental cognitive neuroscience

BACKGROUND: Growing evidence suggests regional and network-level brain imaging features in late childhood are predictive of alcohol use in adolescence. However, the directionality of these effects (i.e. whether they reflect accelerated or delayed neuromaturation) are mixed. We applied a Brain Age Gap Estimation…

2026Altra ricercaTesto disponibile

Common and Differing Elements Across Caregiver-Mediated Social Communication Programs Supporting Autistic Children: A Scoping Review With Content Analysis.

Vipula Rajesh Kumar, Lauren Choi, Janis Oram et al.Autism : the international journal of research and practice

Caregiver-mediated interventions are widely used to support social communication development in young autistic children. While many such interventions are evidence-informed, limited information exists about their shared and unique elements, making it challenging for caregivers and clinicians to tailor program selection to individual needs…

2026Altra ricercaTesto disponibile

Psychotropic medication prescribing to children and young people mental health inpatient services: An English national study.

David Branford, Anne Webster, Marinos Kyriakopoulos et al.Journal of psychopharmacology (Oxford, England)

BACKGROUND: Mental disorders frequently begin in childhood or adolescence. Worldwide, psychotropics are commonly prescribed for under-18s to stabilise behaviour, mood or thoughts. Psychotropics could cause long-term effects on children and young people (CYP) health, growth and development. There is a knowledge gap about…