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Associations Between Types of Physical Activity and Mental Health Among Korean Adolescents: A Cross-Sectional Study Using Data from the 21st Korea Youth Risk Behavior Survey (2025).

Hwang SH, Roh SY, Kim GKBehavioral sciences (Basel, Switzerland)

Adolescence is critical for developing physical activity habits and maintaining mental health. Using data from the 21st Korea Youth Risk Behavior Survey (2025), this cross-sectional study examined the associations between physical activity and mental health in Korean adolescents. The sample included 52,618 middle…

Rethinking Youth Mental Health: Emerging Risks, Transdiagnostic Dimensions, and New Therapeutic Approaches.

Riboldi I, Carrà GBrain sciences

Mental disorders among children, adolescents, and young adults represent a major and growing public health concern [...].

Advances in Mental Health and Well-Being in Children (2nd Edition).

Carmo C, Nunes CChildren (Basel, Switzerland)

The promotion of mental health and well-being in children and adolescents is currently one of the key priorities in research, clinical practice, and public policy [...].

Architect or Destroyer: The Diversity of Glucocorticoid Receptor Signaling Pathways in the Brain.

Shkarina L, Khaybullina R, Primak A et al.International journal of molecular sciences

Glucocorticoids (GCs), acting through the glucocorticoid (GR) and mineralocorticoid (MR) receptors, are essential for brain development, stress adaptation, and metabolic homeostasis, yet their signaling exhibits context-dependent diversity yielding either beneficial or detrimental outcomes. This review synthesizes current knowledge on the multifaceted mechanisms through…

Association between the 2008 financial crisis and suicidal thoughts and behaviors among the United States adolescents: An interrupted time series analysis.

Cai ZM, Xi JY, Luo J et al.Psychiatry research

Association of Copy Number Variations in PTEN with Autism Spectrum Disorder.

Xu Zheng, Ran Tan, Yuze Wang et al.Genes

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong genetic basis. While copy number variations (CNVs) significantly contribute to ASD risk, the specific role of individual genes within these variants remains unclear. This study investigates the contribution of CNVs…

Shared Genetic and Regulatory Architecture of Congenital Heart Disease and Autism Spectrum Disorder Revealed by Cross-Tissue Multi-Omic Integration.

Min Zhu, Jingkun Fred Zhang, Stella X Hu et al.Genes

Background: Congenital heart disease (CHD) and autism spectrum disorder (ASD) co-occur more frequently than expected, suggesting shared developmental susceptibility. We aimed to identify cross-tissue molecular candidates linking cardiac and neurodevelopmental abnormalities. Methods: CHD- and ASD-associated genes were curated from MalaCards and SFARI Gene,…

From Insulin Resistance to Mitochondrial Failure: A Staged Model of Impaired Metabolic Flexibility in Schizophrenia.

Myles Cubitt, Bart Ellenbroek, Anne M HaaseBiomolecules

Schizophrenia is a highly heritable neuropsychiatric disorder whose pathophysiology remains poorly understood. While neurotransmitter, neurodevelopmental, synaptic, and dysconnectivity hypotheses explain important aspects of the disorder, growing evidence suggests that metabolic dysfunction also plays a central role. This narrative review synthesises evidence from genetics,…

Longitudinal Changes in Caregiver Psychological Well-Being and Infant Temperament Following Preterm Birth: From Enrollment to 12 Months Corrected Age.

Lee D, Lee NH, Kim S et al.Children (Basel, Switzerland)

Background: Advances in neonatal care have substantially improved the survival of preterm infants; however, longitudinal changes in caregiver psychological well-being and infant temperament during follow-up remain incompletely understood. This study aimed to characterize changes in caregiver psychological measures and infant temperament from enrollment…

Psychological Well-Being and Short Video Flow in Adolescents: The Moderated-Mediation via Loneliness and Sensation-Seeking.

Makas S, Baloglu MBehavioral sciences (Basel, Switzerland)

In the digital age, adolescents are increasingly using short video apps. Examining the roles of loneliness and sensation seeking is critical to understanding this behavior. This study aims to examine the relationship between psychological well-being and short video flow in adolescents and to…

A Network Analysis of Childhood Psychological Abuse and Overgeneralized Autobiographical Memory in Vocational High School Students.

Liu X, Cao J, Zhang Y et al.Behavioral sciences (Basel, Switzerland)

Background: Overgeneralized autobiographical memory (OGM) has been linked to adolescent psychological difficulties. The CaR-FA-X model proposes that capture and rumination, functional avoidance, and impaired executive control contribute to OGM, and childhood psychological abuse may be embedded in these same processes. Methods: A total…

Epigenetic Hierarchies in Autism from Folate-SAM Metabolism to LSD1 and G9a.

Nuria Pérez, Aina Bellver, Fahad Hussain et al.Biomolecules

Autism spectrum disorder (ASD) is a diverse neurodevelopmental condition involving interactions among genetic, environmental, metabolic, immune, synaptic, and epigenetic factors. This review explores whether disruptions in folate-dependent one-carbon metabolism and S-adenosylmethionine (SAM) availability may increase epigenetic susceptibility in specific ASD subgroups based on…

Enhancing Decision-Making in Pediatric Radiotherapy: Internal Validation and Expansion of the M.A.P.-RT Schedule for Sedation Need Prediction and Identification of Psychological Support Needs in a Prospective Cohort of 268 Pediatric Patients.

Marconi E, Meldolesi E, Mariani S et al.Children (Basel, Switzerland)

Background: Pediatric radiotherapy is often associated with high levels of psychological distress and vulnerability, affecting both patients and their families. In younger children, sedation is frequently required to ensure safety and adequate immobilization during treatment. The original RADAR Project demonstrated that the Multidimensional…

Understanding How Multiple Strengths Support the Mental Health of Adolescents and Young Adults in a Gender-Diverse Sample.

Banyard V, Mitchell KJBehavioral sciences (Basel, Switzerland)

Adolescents and young adults are facing a mental health crisis, with disproportionate burden among youth with diverse gender and sexual identities. Resilience science highlights the importance of modifiable strengths and protective factors as targets for prevention. The Resilience Portfolio Model (RPM) conceptualizes resilience…

Social Media Usage Patterns and Anxiety in Chinese Adolescents: Age-Specific Risks from a Cross-Sectional Perspective.

Liu J, He R, Tie B et al.Behavioral sciences (Basel, Switzerland)

The relationship between social media use and adolescent mental health is complex and multifaceted, with recent findings suggesting that the associations vary according to the nature of social media activities, but the most common social media usage patterns among Chinese adolescents remain insufficiently…

Post-Pandemic Trends of 24-Hour Movement Behaviours and Mental Health Outcomes in Youth.

Ribeiro TD, Peralta M, Marques A et al.Children (Basel, Switzerland)

Background/Objectives: The COVID-19 pandemic disrupted youth movement behaviours and mental health, but evidence on post-pandemic trends remains limited. Therefore, this study examined differences in compliance with the 24-h movement behaviour guidelines and their association with mental health outcomes among Portuguese children and adolescents…

Comparable Acute Antidepressant-like Effects of Two Subanesthetic Ketamine Doses Are Associated with Divergent Region-Specific Molecular Responses After Adolescent Chronic Stress.

Zivanovic A, Lukic I, Glavonic E et al.International journal of molecular sciences

Ketamine produces rapid antidepressant-like effects across a range of subanesthetic doses, yet how dose shapes behavioral efficacy and region-specific molecular signaling following adolescent chronic unpredictable stress (CUS) is not well understood. Here, we examined the behavioral and molecular consequences of two subanesthetic ketamine…

Custody arrangements and the mental health of adolescents and their parents in the United Kingdom: A longitudinal analysis using understanding society.

Gondek D, Bernardi LSocial science & medicine (1982)

The Modifying Role of Cortisol in the Sex-Specific Associations of Social Jetlag with Neurobehavioral Problems Among Adolescents: The Shanghai Adolescent Cohort Study.

Peng J, Jiang Y, Zhu D et al.Nature and science of sleep

Neighborhood violence, visible drug activity, and substance use among urban youth: Mental health and community factors.

Weerakoon SM, Opara-Mezue IDrug and alcohol dependence