6 Novembre 2026

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2026Altra ricercaTesto disponibile

[Mapping municipal psychosocial services for children and parents: access and coordination barriers in preventive care-a mixed methods study].

Sarah Beierle, Anika Reinhart, Susanne Kuger et al.Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz

BACKGROUND: Services for the primary and secondary prevention of mental disorders in children are distributed across the health, education and social sectors. Comprehensive prevention requires their coordinated collaboration at the municipal level. However, there is currently no systematic scientific assessment of municipal psychosocial…

2026Altra ricercaTesto disponibile

The path to treating multiple-etiology dementia: Combining vascular risk control and disease-modifying neurodegenerative therapies.

Adam de Havenon, Kevin N Sheth, Carolyn A Fredericks et al.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Multiple-etiology dementia (MED), typically characterized by coexisting vascular and neurodegenerative pathology, is the most common cause of late-life cognitive impairment. Autopsy and biomarker studies demonstrate frequent overlap between cerebral small vessel disease, stroke-related injury, amyloid-β deposition, and tau pathology, yet therapeutic development has…

2026Altra ricercaTesto disponibile

Pharmacological modulation of cGAS-STING-NLRP3 signaling by nano-immunomodulators in Alzheimer and Parkinson disease.

Mohammed A Abdel-RasolInflammopharmacology

Neuroinflammation is a central driver of neurodegeneration in Alzheimer's disease (AD) and Parkinson's disease (PD), driven by interconnected pathways involving microglial state dysregulation, inflammasome activation, cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling, impaired mitophagy, CD33-TREM2 imbalance, gut-brain axis disruption, and peripheral immune…