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Social Determinants of Health and Neurocognitive Aging in Indigenous and Non-Indigenous Older Adults in Rural Andean Ecuador: A Population-Based Study in Cotacachi.

Tituaña-Vega K, Palacios-León I, Paredes-Manrique C et al.Brain sciences

Introduction: Social determinants of health shape dementia risk in Latin America, particularly in rural and Indigenous populations. Methods: This cross-sectional study examined cognitive impairment and associated social factors in 75 adults aged 60 years or older in Cotacachi, Ecuador, identifying as Indigenous, Mestizo,…

Development and Internal Validation of Multivariable Prediction Models for Depression, Anxiety, and Stress Among Saudi Adolescent Video Game Players: A Cross-Sectional Study.

Asiri A, Alshahrani A, Korairi H et al.Behavioral sciences (Basel, Switzerland)

BackgroundAnxiety, stress, and depression are increasingly prevalent mental health problems among adolescents, and several studies have reported significant associations between these conditions and video game addiction. The present study was therefore conducted to develop and internally validate multivariable prediction models based on gaming-related…

Chronic stress activates a hypothalamic vagal circuit to promote hepatocellular carcinoma progression in male mice.

Zhang K, Zhang J, Chi D et al.Nature communications

Caring for the Caregivers: A Narrative Review of Physician Health Protection Across High-Income Countries and Lessons for Low- and Middle-Income Countries.

Razaq HB, Saeed O, Reshtin M et al.Cureus

The Process of Maternal Recognition of and Response to Suspected Gaming Disorder Among Japanese Adolescents Receiving Psychiatric Outpatient Care: A Qualitative Study.

Takahara D, Takahara M, Nonaka DCureus

The Effects of a Multi-Strain Probiotic Formulation Containing Saffron Extract and Fructooligosaccharides on Anxiety, Depressive Symptoms, Inflammatory Markers, and BDNF: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.

Demetriou M, Theleritis C, Alevyzakis E et al.Microorganisms

Depression and anxiety are highly prevalent mental health conditions, with growing evidence implicating the gut-brain-immune axis in their pathophysiology. Probiotic supplementation has emerged as a potential psychobiotic intervention, although clinical findings remain inconsistent. This double-blind, randomized, placebo-controlled pilot study assessed the feasibility of…

Depression, C-Reactive Protein, and the Risk of Mortality During Middle and Late Adulthood.

Banerjee S, Khubchandani J, Beydoun MA et al.Epidemiologia (Basel, Switzerland)

Background and Purpose: Mental illnesses, including depression, are major contributors to disability and health loss globally. Research has increasingly focused on identifying biochemical markers, such as C-reactive protein (CRP), to better understand the link between systemic inflammation and psychiatric disorders. However, the long-term…

Patterns of Pronoun Affirmation Across Social Contexts and Opportunities for Resilience Among Trans and Nonbinary Youth.

Garcia AN, Toomey RB, Abreu RLBehavioral sciences (Basel, Switzerland)

This study examined chosen pronoun affirmation across multiple social contexts (i.e., home, online school, in-person school, work, friends, and extended family) as a predictor of mental health among 319 trans and nonbinary (TNB) youth (ages: 13-22; Mage = 18.6, SD = 2.18). Pronoun…

Associations of Depression and Antidepressant Use with the Risk of Tuberculosis Sequelae: Insight from Genetic Analysis.

Chen T, Ge L, Zhang D et al.Genes

Background: Depression and antidepressant use have been suggested to be associated with tuberculosis sequelae, but whether these associations are causal remains unclear. We aimed to investigate the potential associations of genetically predicted depression and antidepressant use with the risk of tuberculosis sequelae using…

A Hybrid AI-Assisted Framework for Anxiety Support: System Description and Exploratory Findings Among University Students.

Rostami P, Bakhtiari E, Baharizadeh B et al.Behavioral sciences (Basel, Switzerland)

A growing number of individuals experiencing anxiety and other mental health difficulties require accessible approaches to mental health support. This paper presents a hybrid AI-assisted framework designed as a potential complementary support tool for future therapist-supervised mental health care rather than as a…

Profile of risk factors for people who inject drugs among a sample at high risk of HIV/AIDS in Kigali, Rwanda.

Habimana S, Lister Z, Biracyaza E et al.Advances in drug and alcohol research

BackgroundThe increasing prevalence of people who inject drugs (PWID) among populations at high risk for human immunodeficiency virus (HIV) has become a critical public health concern, particularly in Africa. This issue is associated with substantial health-related effects among populations at high risk for…

Sex-Specific Differences in Symptomatology and Quality of Life Impact of Allergic Rhinitis: A Cross-Sectional Study.

Al-Balas HI, Khamees A, Al Saoud SK et al.Immunity, inflammation and disease

BackgroundAllergic Rhinitis (AR) is a widespread condition that significantly affects the quality of life (QOL) of those affected globally. It contributes to sleep disturbances, fatigue, poor concentration, irritability, and can worsen symptoms in individuals with coexisting asthma. This study examines the impact of…

Proteomic Features and Association Analysis of Late-Onset Depression Based on Behavioral Factorial Analysis and Proteomics.

Yan Y, Xu H, Zhang T et al.Journal of proteome research

Moderating Role of Social Support Between Financial Hardship and Quality of Life in Breast Cancer Survivors.

Yi JC, Paras G, Barnett MJ et al.Psycho-oncology

A Multilevel Mental Health Intervention with Latine Newcomers: The Feasibility and Mixed Methods Results of a Community-Based Participatory Pilot Study.

Blackwell MA, Lardier DT, Hess JM et al.Behavioral sciences (Basel, Switzerland)

Latine immigrants in the U.S. face discrimination, a lack of access to resources, fear of deportation, family separation, and a lack of understanding of the complex factors that have led them to seek safety and survival in a new country, factors that critically…

The Mediating Role of Resilience in the Association Between Anxiety and Depressive Symptoms Among College Students at a Hispanic-Serving Institution in a U.S.-Mexico Border Region.

Torregosa MB, Patricio OMBehavioral sciences (Basel, Switzerland)

Anxiety and depressive symptoms are prevalent concerns among college students, yet less is known about the role of resilience in their association among students in U.S.-Mexico border regions. This cross-sectional study examined whether resilience statistically mediated the association between anxiety and depressive symptoms…

Severity Profiles of Smartphone Addiction and Mental Health Differences from the Perspective of Adolescent Development: A Latent Profile Analysis.

Zhang N, Gao X, Yang Y et al.Behavioral sciences (Basel, Switzerland)

IntroductionIn the digital age, smartphones may amplify adolescents' developmental vulnerability, making their mental health more likely to be affected by problematic smartphone use. However, prior research has largely overlooked adolescents' developmental characteristics and individual differences.MethodsThis study employed latent profile analysis (LPA) to identify…

Voice and speech as digital biomarkers of mental health: a scoping review of clinical interpretability, data collection and translational readiness.

Uy RJ, Shaaban I, Arnaout AFrontiers in digital health

BackgroundVoice and speech encode acoustic, linguistic, and interactional information associated with mental health. Translating these signals into clinically meaningful digital biomarkers depends not only on predictive performance but on how speech is elicited, how the target state is defined, whether findings generalize beyond…

Neurobiological insights into psychotic depression from magnetic resonance imaging: a systematic review.

Yue Ming, Qian Zhang, Aoxiang Zhang et al.Journal of psychiatry & neuroscience : JPN

R-GCRED: a retrieval-grounded and calibrated risk estimation for depression prediction and screening recommendation framework.

Saidi F, Almulla MFrontiers in artificial intelligence

Early depression detection from textual narratives has advanced substantially with transformer-based language models and Large Language Models (LLMs). However, reliable screening-oriented decision support requires more than high predictive accuracy. Existing approaches often lack explicit symptom-level grounding, produce poorly calibrated confidence estimates, and provide…