3 Novembre 2026

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Plasma exosomal microRNA profiles associated with agitation symptoms in schizophrenia.

Yucheng Ling, Yifan Wang, Ruiqiu Zhu et al.BMC psychiatry

BACKGROUND: Inflammatory dysregulation and synaptic dysfunction have been implicated in the pathophysiology of agitation in schizophrenia (SZ), but the underlying molecular mechanisms remain unclear. Plasma exosomal microRNAs (miRNAs) are stable circulating molecules that may reflect disease-related molecular alterations associated with schizophrenia. This study…

2026Altra ricercaTesto disponibile

A canonical microcircuit for estimating Excitation/Inhibition (E/I) balance.

Daniel J Hauke, Julia Rodriguez-Sanchez, Hope Oloye et al.Translational psychiatry

Excitation/inhibition (E/I) balance is crucial for maintaining healthy brain function and can be disrupted in various neurological and psychiatric disorders. Despite its importance, there are few tools to study E/I balance non-invasively in humans. Here, we propose a canonical microcircuit model to estimate…

2026Altra ricercaTesto disponibile

Experience sampling reveals habitual and transdiagnostic properties of compulsivity.

Teckentrup V, Fox CA, Donegan KR et al.Translational psychiatry

Both obsessive thoughts and an urge to act have been linked to compulsions cross-sectionally. However, prominent theories of compulsivity disagree quite fundamentally about whether compulsions are goal-oriented attempts to reduce or eliminate obsessive thoughts or are urge-driven and habitual. To shed light on…