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Neural and Multimodal Signatures of Threat Learning, Generalization, and Return of Fear linked to Adverse Childhood Experiences

Ruge J, Ehlers M, Sommer T et al.

The Psychological Boundaries of Attachment: A Systematic Review on Identity Fusion, Self-Expansion, and the Cognitive Overlap with Romantic Partners Versus Social Acquaintances

Momin M

OLFM4, LCN2 and FAM3B as Potential Biomarkers for Gut-Brain Axis Dysfunction in IBD-MDD Comorbidity.

Fang Li, Junmei Zhao, Boyang Song et al.Genes

BACKGROUND: Inflammatory bowel disease (IBD) and major depressive disorder (MDD) exhibit bidirectional pathogenic interactions through the gut-immune-brain axis, but robust common biomarkers remain elusive. This study aimed to identify the core hub genes and their conserved signaling pathways in IBD-MDD comorbidity. METHODS: We…

Do People Dream of Sex with Androids? Neuroscience Behind Cybersex and Technosexual Behaviour.

Gerymski RBrain sciences

Technology-mediated sexual behaviours, including cybersex and technosex, are becoming increasingly prevalent as digital technologies, virtual reality, artificial intelligence, and interactive devices continue to develop. Although these behaviours may offer numerous benefits, such as facilitating sexual exploration, supporting individuals with disabilities, and enabling long-distance…

Chromosome 14 MicroRNA Cluster Members in Brain-Derived Extracellular Vesicles Can Be Genotype-Associated Biomarker Candidates for Alzheimer's Disease and Frontotemporal Dementia.

Joseph Morgan, Toby Aarons, Gemma Lace et al.Biomolecules

BACKGROUND: The chromosome 14 microRNA cluster (C14MC) is the second largest microRNA (miRNA) cluster in the human genome, which is tightly regulated during early development and dysregulated in many disease conditions. Members of this cluster are reported to have important temporal and spatial…

Ocular Phototherapy and Mental Health: What Vision Scientists and Clinicians Need to Know

Peterzell DH

The art of permeability: A computational distinction between depersonalisation and advanced meditation

Saini F, Tal H, Laukkonen RE et al.

Problematic social media and gaming use, screen time, and youth mental health and brain structure in the ABCD Study

Lo W, Lopez RB, Nephew B

Concussion, attention, and mental health: A brain network study in youth (CAMBY) – Study protocol

Scratch SE, Gill PK, Hickling A et al.

Multi-Cohort Transcriptomic Integration Identifies Overlapping Immune and Antigen-Presentation Features in Alzheimer's Disease and Hashimoto's Thyroiditis.

Shuting Zhong, Guanfeng Xie, Zhaohui ZhangGenes

BACKGROUND: Thyroid disorders and Alzheimer's disease (AD) have been linked epidemiologically, but whether AD brain tissue and thyroid tissue affected by Hashimoto's thyroiditis (HT) share molecular features remains unclear. METHODS: Differential expression was estimated in AD (GSE122063) and HT (GSE138198) discovery cohorts using…

Hemicyanine-Based Wash-Free Near-Infrared Fluorescent Probe for Imaging Amyloid-β Aggregates in Alzheimer's Disease.

Xueqi Zhao, Rundong Liang, Yao Li et al.Molecules (Basel, Switzerland)

As a key biomarker of Alzheimer's disease (AD), amyloid-β (Aβ) is frequently employed for the diagnosis of AD. Near-infrared fluorescence (NIRF) imaging is a non-invasive, low-cost route for visualizing Aβ in vivo. However, most existing Aβ NIRF probes require tedious washing steps, show…

Immunometabolic crosstalk between dysfunctional adipose tissue and the brain: implications for postoperative cognitive dysfunction in obesity.

Ya-Jiao Hu, Juan Ni, Jin-Xi ZhangFrontiers in immunology

Postoperative cognitive dysfunction (POCD) is an important complication after surgery, particularly in patients with pre-existing metabolic and inflammatory vulnerability. Obesity may increase susceptibility to postoperative cognitive decline, but its independent association with POCD and the underlying mechanisms remain uncertain. This review critically examines…

Korean Buddhist Temple Food: A Traditional Plant-Based Dietary Pattern Linking Gut Microbiota, Metabolic Health, and Mindful Living.

Hae-Ji Kang, Young Hoon Jung, Jungwoo Yang et al.Nutrients

Korean Buddhist temple food represents a traditional plant-based dietary practice rooted in Korean Buddhist monastic traditions and characterized by an emphasis on seasonal and minimally processed plant foods. Traditional temple-food practices generally exclude pungent vegetables-such as garlic, green onion, chives, wild garlic, and…

The Influence of Neurotic Disorders and Neurobiological Basis on Eating Behavior in a 21-Year-Old Patient: A Case Study-Diagnostic Difficulties: Is It PANDAS/PANS in Relation to an Elevated ASO Level and the Diagnosis of OCD?

Zygo A, Regin KJ, Purkiewicz AJournal of clinical medicine

Background: Anxiety and obsessive-compulsive disorders can co-occur with disordered eating behaviors and difficulties in emotional regulation. This article presents the clinical case of a 21-year-old female student whose complex neuropsychiatric profile required the simultaneous consideration of psychological, psychosocial, and somatic factors. The aim…

Flocculent Ti3AlC2-Based Two-Dimensional Material Flexible Microneedle Patch for Screening Alzheimer's Disease Animal Biomarkers and In Situ Revealing Spatial Aggregation of Arachidonic Acid.

Siyuan Chen, Bixiang Li, Tangjing Zhao et al.Molecules (Basel, Switzerland)

Efficient diagnosis and pathological elucidation of Alzheimer's disease (AD) are constrained by the lack of technologies for in situ capture of metabolites in living brain tissues. Metabolic disorders in the parietal lobe highly correlate with AD progression, yet existing methods cannot achieve in…

AI-Assisted WES Variant Interpretation in Neurodevelopmental Disorders: A Narrative Review of Existing Tools.

Simone Treccarichi, Mirella Vinci, Antonino Musumeci et al.Genes

Background/Objectives: Neurodevelopmental disorders (NDDs) comprise a heterogeneous group of conditions characterized by alterations in brain development and function, frequently associated with complex genetic architectures. The widespread implementation of next-generation sequencing, particularly whole-exome sequencing (WES), has substantially increased the identification of potentially disease-associated variants,…

GWAS of Active Music Engagement Frequency in the Canadian Longitudinal Study on Aging

Henechowicz T, Wolford B, Nitin R et al.

Conceptualizing Cognitive Growth and Release: Integrating Adult Development into Contemplative Science

Murray T, McConkie T, Sacchet M

Chronic Ultrasound ('Emotional') Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention.

Gorlova A, Haque A, Reid N et al.International journal of molecular sciences

Background: Growing evidence supports a bidirectional relationship between 'emotional' (psychological) stress and intestinal inflammation. 'Emotional stress', a form of stress that is triggered by negative information and experiences of non-physical nature, is an established risk factor for the development of subclinical intestinal inflammation,…

Alpiniae oxyphyllae Fructus in Alzheimer's Disease: Multi-Target Mechanisms, Current Evidence, and Future AI-Driven Perspectives.

Qihan Qin, Qingmin Yan, Keyi Zhu et al.Molecules (Basel, Switzerland)

Alpiniae oxyphyllae Fructus (Zingiberaceae; Alpinia oxyphylla Miq) (AOF) is a traditional Chinese medicinal and edible homologous material rich in bioactive metabolites, including flavonoids, terpenes, and sesquiterpenes. Its multiple metabolites and multi-target nature confer unique advantages for cognitive function and neuroprotection. However, recent advances…