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Accedi come professionistaKönigstein D, Kisko TM, Michels S et al.Biomolecules
The CACNA1C gene encodes the α1C subunit of voltage-gated CaV1.2 calcium channels, serving many pivotal functions throughout the body, including in the heart and brain. Clinical and genetic evidence implicates altered expression and/or function of CACNA1C/CaV1.2 in both cardiac and neuropsychiatric disease, including…
Yamasaki T
Ruge J, Ehlers M, Sommer T et al.
Momin M
Fang Li, Junmei Zhao, Boyang Song et al.Genes
BACKGROUND: Inflammatory bowel disease (IBD) and major depressive disorder (MDD) exhibit bidirectional pathogenic interactions through the gut-immune-brain axis, but robust common biomarkers remain elusive. This study aimed to identify the core hub genes and their conserved signaling pathways in IBD-MDD comorbidity. METHODS: We…
Gerymski RBrain sciences
Technology-mediated sexual behaviours, including cybersex and technosex, are becoming increasingly prevalent as digital technologies, virtual reality, artificial intelligence, and interactive devices continue to develop. Although these behaviours may offer numerous benefits, such as facilitating sexual exploration, supporting individuals with disabilities, and enabling long-distance…
Joseph Morgan, Toby Aarons, Gemma Lace et al.Biomolecules
BACKGROUND: The chromosome 14 microRNA cluster (C14MC) is the second largest microRNA (miRNA) cluster in the human genome, which is tightly regulated during early development and dysregulated in many disease conditions. Members of this cluster are reported to have important temporal and spatial…
Peterzell DH
Saini F, Tal H, Laukkonen RE et al.
Lo W, Lopez RB, Nephew B
Scratch SE, Gill PK, Hickling A et al.
Shuting Zhong, Guanfeng Xie, Zhaohui ZhangGenes
BACKGROUND: Thyroid disorders and Alzheimer's disease (AD) have been linked epidemiologically, but whether AD brain tissue and thyroid tissue affected by Hashimoto's thyroiditis (HT) share molecular features remains unclear. METHODS: Differential expression was estimated in AD (GSE122063) and HT (GSE138198) discovery cohorts using…
Xueqi Zhao, Rundong Liang, Yao Li et al.Molecules (Basel, Switzerland)
As a key biomarker of Alzheimer's disease (AD), amyloid-β (Aβ) is frequently employed for the diagnosis of AD. Near-infrared fluorescence (NIRF) imaging is a non-invasive, low-cost route for visualizing Aβ in vivo. However, most existing Aβ NIRF probes require tedious washing steps, show…
Ya-Jiao Hu, Juan Ni, Jin-Xi ZhangFrontiers in immunology
Postoperative cognitive dysfunction (POCD) is an important complication after surgery, particularly in patients with pre-existing metabolic and inflammatory vulnerability. Obesity may increase susceptibility to postoperative cognitive decline, but its independent association with POCD and the underlying mechanisms remain uncertain. This review critically examines…
Hae-Ji Kang, Young Hoon Jung, Jungwoo Yang et al.Nutrients
Korean Buddhist temple food represents a traditional plant-based dietary practice rooted in Korean Buddhist monastic traditions and characterized by an emphasis on seasonal and minimally processed plant foods. Traditional temple-food practices generally exclude pungent vegetables-such as garlic, green onion, chives, wild garlic, and…
Zygo A, Regin KJ, Purkiewicz AJournal of clinical medicine
Background: Anxiety and obsessive-compulsive disorders can co-occur with disordered eating behaviors and difficulties in emotional regulation. This article presents the clinical case of a 21-year-old female student whose complex neuropsychiatric profile required the simultaneous consideration of psychological, psychosocial, and somatic factors. The aim…
Siyuan Chen, Bixiang Li, Tangjing Zhao et al.Molecules (Basel, Switzerland)
Efficient diagnosis and pathological elucidation of Alzheimer's disease (AD) are constrained by the lack of technologies for in situ capture of metabolites in living brain tissues. Metabolic disorders in the parietal lobe highly correlate with AD progression, yet existing methods cannot achieve in…
Simone Treccarichi, Mirella Vinci, Antonino Musumeci et al.Genes
Background/Objectives: Neurodevelopmental disorders (NDDs) comprise a heterogeneous group of conditions characterized by alterations in brain development and function, frequently associated with complex genetic architectures. The widespread implementation of next-generation sequencing, particularly whole-exome sequencing (WES), has substantially increased the identification of potentially disease-associated variants,…
Henechowicz T, Wolford B, Nitin R et al.
Murray T, McConkie T, Sacchet M