GABAergic Network Dysregulation in Alcohol Use Disorder: Receptor-Transporter Interactions Driving the Transition From Goal-Directed to Compulsive Behaviour.
Hannah Aranda, Nathan Jones, Humza Haroon et al.Addiction biology
Alcohol use disorder (AUD) is characterized by a shift from controlled, goal-directed drinking to compulsive, habitual alcohol (a.k.a. ethanol) seeking, even in the face of negative outcomes. This transition is closely associated with alterations in cortico-striatal circuitry and dysregulated GABAergic signalling, both of…