3 Novembre 2026

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Endoplasmic Reticulum Autophagy Enhancement Alleviates Synaptic Plasticity Dysfunction and Ameliorates Cognitive Impairment in SAE Mice by Relieving STING-Associated Inhibition of PKM2 Activity.

Xiaofeng Guo, Daqing Yin, Zhonghua Zhang et al.CNS neuroscience & therapeutics

BACKGROUND: The pathogenesis of cognitive impairment in patients with sepsis-associated encephalopathy (SAE) remains unclear. This study investigated whether enhancing micro-endoplasmic reticulum autophagy (micro-ER-phagy) could alleviate synaptic dysfunction and improve cognitive impairment in SAE mice models by relieving stimulator of interferon gene (STING)-associated inhibition…

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Time Flows With the Changing of Events.

Matthew Logie, Marianna Lamprou-Kokolaki, Virginie van WassenhoveAnnals of the New York Academy of Sciences

In recent years, investigations into the psychological experience of time have rapidly accelerated. The experience of time could depend on a ticking internal clock or rely on contextual changes within and between events. Cognitive theories of memory propose that the presence of event…