4 Novembre 2026

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2026Altra ricercaTesto disponibile

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease.

Junyi Liang, Huawen Cao, Xiumin Ren et al.Aging cell

Aging, neuroinflammation and metabolic dysfunction are tightly intertwined in Alzheimer's disease (AD), but how transient pathological signals become persistent cellular states remains poorly understood. Histone post-translational modifications (PTMs) provide a dynamic interface between extracellular stimuli, cellular metabolism and chromatin state. This Review examines…

2026Altra ricercaTesto disponibile

Neurophysiological and Behavioural Effects of Combined Cannabis Concentrates and Alcohol Among People Who Regularly Use Alcohol and Cannabis.

Eleftherios M Hetelekides, Patricia L Davies, Mark A Prince et al.Addiction biology

Increasingly potent concentrated cannabis products containing high levels of Δ9-tetrahydrocannabinol (THC) are being consumed with alcohol. This combination is known to acutely impair cognitive and psychomotor abilities, although few studies have evaluated alcohol and cannabis co-use using neural measures. This naturalistic feasibility study…

2026Altra ricercaTesto disponibile

Social motivation and sensory over-responsivity: Independent correlates of picky eating severity in early childhood.

Nocera A, Gu SJ, Schwarzlose RF et al.Appetite. Disordered eating

OBJECTIVE: Picky eating is common in children, but when persistent, is predictive of Avoidant/Restrictive Food Intake Disorder (ARFID). Multiple factors have been individually associated with picky eating severity in early childhood, but these rarely have been modeled simultaneously, leaving the relative importance of…

2026Altra ricercaTesto disponibile

Intrinsic capacity decline and self-rated health in patients ≥ 65 years: a survey in general practice waiting rooms in Norway.

Sebjørnsen I, Bakken MS, Hjörleifsson S et al.Scandinavian journal of primary health care

OBJECTIVES: To examine the prevalence of, and factors associated with, intrinsic capacity (IC) decline among older adults in Norwegian general practice. Second, to assess how IC decline relates to self-rated health (SRH). DESIGN AND SETTING: Survey examination in general practice waiting rooms in…

2026Altra ricercaTesto disponibile

Alzheimer's genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis.

Adeline E Walsh, Benjamin A Davis, Joshua D Samuels et al.The Journal of experimental medicine

Recent genome-wide association studies have identified numerous Alzheimer's disease (AD) risk genes enriched in microglia, including Crk-associated substrate (Cas) scaffold protein family member 4 (CASS4), which encodes the adaptor protein CASS4. Despite its strong genetic association with AD, the role of CASS4 in…