La ricerca in psicologia,
più accessibile.

Effectiveness of AI-Driven Digital Mental Health Interventions and Their Implications for Health Service Delivery: A Systematic Review and Meta-Analysis (2013–2025)

Nursalim¹ M, Saroinsong¹ WP, Ledger³ S et al.

Tutorbot pilot study: learning support, feedback and assessment in a crisis intervention module

Hermann C, Chanza M

Producción científica estudiantil y Agenda 2030: análisis lexicométrico asistido por inteligencia artificial en pregrado

Martínez Vizcaíno GI

Self-harm incidents and restrictive practice use in an acute female inpatient unit: a service evaluation of a continuous multi-system improvement approach

Johnson S, Kelbrick M, Griffiths C et al.

Predictors of methadone response in chronic neuropathic pain

Barbosa MM, Pentiado Júnior JAM, Kubota GT et al.

Chronic Ultrasound ('Emotional') Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention.

Gorlova A, Haque A, Reid N et al.International journal of molecular sciences

Background: Growing evidence supports a bidirectional relationship between 'emotional' (psychological) stress and intestinal inflammation. 'Emotional stress', a form of stress that is triggered by negative information and experiences of non-physical nature, is an established risk factor for the development of subclinical intestinal inflammation,…

Effect of Leucovorin on Mitochondrial Respiration and One-Carbon Metabolism in Autism Spectrum Disorder: A Double-Blind Placebo-Controlled Substudy.

Shannon Rose, Stepan Melnyk, S Jill James et al.International journal of molecular sciences

Mitochondrial dysfunction and impaired methylation are implicated in autism spectrum disorder (ASD). Leucovorin, a reduced folate that bypasses both dihydrofolate reductase and folate receptor alpha, has shown clinical benefit in small trials in children with ASD, but the underlying biology is incompletely understood.…

Peptides and Peptide Analogues Targeting Acetylcholinesterase-Associated Mechanisms in Alzheimer's Disease and Dementias: Evidence Gaps, Design Strategies, and Translational Perspectives.

Joanna Zdunek, Błażej GrodnerInternational journal of molecular sciences

Alzheimer's disease and related dementias involve interacting disturbances in amyloid-β, tau, neuroinflammation, oxidative stress, mitochondrial function, synaptic integrity, and cholinergic neurotransmission. Acetylcholinesterase, in addition to terminating cholinergic signalling through acetylcholine hydrolysis, participates in non-catalytic interactions associated with amyloid-β, providing a mechanistic rationale for…

Diagnostic Yield and Clinical Actionability of Genetic Testing in Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis.

Alexandra Aurora Dumitra, Ioana Streață, Adina Turcu-Știolică et al.International journal of molecular sciences

Genetic testing is increasingly central to the evaluation of neurodevelopmental disorders (NDDs), yet most evidence emphasises diagnostic yield rather than whether findings change clinical care. We conducted a systematic review and meta-analysis (Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA] 2020) of…

Cord Blood 3-Epi-25-Hydroxyvitamin D3 and Autism-Related Cognitive Traits at Age 10 Years: An Exploratory Secondary Analysis of the KLOTHO Birth Cohort.

Spyridon N Karras, Dimitrios G Goulis, Maria Dalamaga et al.Nutrients

BACKGROUND: The C3 epimer of 25-hydroxyvitamin D3 [3-epi-25(OH)D3] can be measured in maternal and umbilical cord circulation, but whether it is related to later neurodevelopment is unknown. OBJECTIVE: To explore associations between cord 3-epi-25(OH)D3 and parent-reported autism-related trait domains at 10 years in…

Weight Loss and Long-Term Weight Trajectories After a Structured Nutritional and Behavioral Intervention: A Large Real-World Cohort Study.

Odile Fabre, Sébastien Bailly, Laurent Pantagis et al.Nutrients

BACKGROUND/OBJECTIVES: Achieving and maintaining intentional weight loss is a major challenge in routine clinical practice, and real-world evidence is limited. METHODS: This retrospective cohort study evaluated initial weight loss in 56,093 adults from a total of 126,659 who commenced the French RNPC program…

Alpiniae oxyphyllae Fructus in Alzheimer's Disease: Multi-Target Mechanisms, Current Evidence, and Future AI-Driven Perspectives.

Qihan Qin, Qingmin Yan, Keyi Zhu et al.Molecules (Basel, Switzerland)

Alpiniae oxyphyllae Fructus (Zingiberaceae; Alpinia oxyphylla Miq) (AOF) is a traditional Chinese medicinal and edible homologous material rich in bioactive metabolites, including flavonoids, terpenes, and sesquiterpenes. Its multiple metabolites and multi-target nature confer unique advantages for cognitive function and neuroprotection. However, recent advances…

Clinical and Molecular Spectrum of 1q21.1 Copy Number Variations: A Case Series.

Tuna Eren Esen, Lale Yilmaz Celik, Aydeniz Aydin Gumus et al.Genes

BACKGROUND: 1q21.1 copy number variations (CNVs) are recurrent rearrangements with a clinical spectrum, from neurodevelopmental disorders and congenital anomalies to apparently unaffected carrier status, reflecting incomplete penetrance and variable expressivity. METHODS: Our chromosomal microarray (CytoScan HD) database was retrospectively screened for pathogenic or…

Bridging the Human-AI Trust Gap: The Mechanisms Underlying Perceived Efficacy of AI-Powered Psychological Counseling Large Language Models.

Wang Y, Yin M, Lv KBehavioral sciences (Basel, Switzerland)

Artificial intelligence (AI) is transforming the delivery of mental health services, yet public trust in AI-based psychological counseling remains a significant challenge. Drawing on a "technology-context-trust" framework, this study recruited a total of 1000 consumers in China through Credamo and conducted five between-subjects,…

From Limb Salvage to Prosthetic Rehabilitation After Severe Traumatic Hand Injury Complicated by Complex Regional Pain Syndrome: A Case Report.

Tot OK, Petričević A, Hnatešen D et al.Journal of clinical medicine

Background/Objectives: Severe traumatic injuries of the upper extremity present a major therapeutic challenge because of extensive tissue damage, severe pain, loss of function, and substantial psychosocial consequences. Continuous multidisciplinary rehabilitation that adapts to the patient's evolving clinical condition may optimize functional outcomes across…

Prognostic Nutritional Index, Circulating Bacterial and Viral DNA, and Neurocognitive Vulnerability in Geriatric Inpatients: A Cross-Sectional Study.

Gretta Veronica Badillo Pazmay, Patrizia D'Aquila, Carlo Fortunato et al.Nutrients

BACKGROUND/OBJECTIVES: Impaired immunonutritional status is common among hospitalized older adults and may contribute to adverse outcomes through alterations in gut-brain axis pathways involving immune, microbial, and inflammatory mechanisms. The Prognostic Nutritional Index (PNI), a composite marker based on serum albumin and lymphocyte count,…

MUSA: A Multimodal MRI-Based Major Depressive Disorder Classification Model with a Unified ROI Semantic Space.

Honghua Wang, Xiuwei Peng, Han Wu et al.Sensors (Basel, Switzerland)

Major depressive disorder (MDD) is a common disabling psychiatric disorder mainly diagnosed through clinical interviews and rating-scale assessments. Magnetic resonance imaging (MRI) provides a promising basis for computer-aided MDD identification, particularly through multimodal models that can integrate structural and functional brain information. However,…

Atrial Septal Aneurysm and Anxiety: A Matched Cross-Sectional Study with Prospective Enrollment Exploring Clinical and Psychosomatic Associations.

Gürbüz DÇ, Atmaca H, Damar H et al.Journal of clinical medicine

Background/Objectives: An isolated atrial septal aneurysm (ASA) represents a distinct structural anomaly defined by abnormal bulging of the interatrial tissue, affecting roughly three percent of the general public. Although routinely viewed as an accidental discovery during imaging, this condition carries recognized associations with…

Integrative Genetic and Transcriptomic Analysis Reveals Candidate Molecular Differences Among Dementia with Lewy Bodies, Alzheimer's Disease, and Parkinson's Disease Dementia.

Gözde Öztan, Tuğçe İşsever, Halim İşseverInternational journal of molecular sciences

Dementia with Lewy bodies (DLB) shares substantial clinical and molecular features with Alzheimer's disease (AD) and Parkinson's disease dementia (PDD), complicating the identification of disease-specific molecular alterations. This study aimed to characterize transcriptomic differences among these disorders and to integrate expression findings with…

Sleep Disturbances and Circadian Phase Delay in People Living with Human Immunodeficiency Virus (HIV): A Systematic Review.

Antoni Gomila-Cardona, Saúl Ferrández-Sempere, Francesca Cañellas et al.International journal of molecular sciences

Advances in HIV research and antiretroviral therapy (ART) have substantially increased life expectancy among people living with HIV (PLHIV). However, challenges affecting quality of life and alterations in daily physiological processes persist. Among the health dimensions most affected are sleep quality and circadian…